Human URAT1 bound with Uric acid
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 9jdv
Q-score: 0.344
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Human uric acid transporter 1 with uric acid (Complex from Homo sapiens)
- Uric acid (168 Da, Ligand)
Human URAT1 bound to lesinurad
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9jdz
Q-score: 0.361
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Lesinurad (404 Da, Ligand)
- Water (18 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Human uric acid transportor 1 with lesinurad (Complex from Homo sapiens)
Human URAT1 bound to benzbromarone
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9je0
Q-score: 0.363
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Human uric acid transporter 1 with benzbromarone (Complex from Homo sapiens)
- [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone (424 Da, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7yk6
Q-score: 0.419
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
- 1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1h-indol-3-yl)methylideneamino]guanidine (383 Da, Ligand)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with compound 4 and g protein (Complex)
Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8gua
Q-score: 0.484
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2215621119-e2215621119 [ Pubmed: 36343266 DOI: doi:10.1073/pnas.2215621119 ]
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (441 Da, Ligand)
- Human pi3kalpha mutant e542k in complex with byl-719 (Complex from Homo sapiens)
Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8gub
Q-score: 0.531
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2215621119-e2215621119 [ Pubmed: 36343266 DOI: doi:10.1073/pnas.2215621119 ]
- Human pi3kalpha mutant h1047r in complex with byl-719 (Complex from Homo sapiens)
- (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (441 Da, Ligand)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8gud
Q-score: 0.44
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2215621119-e2215621119 [ Pubmed: 36343266 DOI: doi:10.1073/pnas.2215621119 ]
- (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (441 Da, Ligand)
- Cryo-em structure of pi3kalpha mutant e545k in complex with byl-719 (Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
PI 3-kinase alpha with nanobody 3-126
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8dcp
Q-score: 0.584
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ Pubmed: 36095215 DOI: doi:10.1073/pnas.2210769119 ]
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-126 bound (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
PI 3-kinase alpha with nanobody 3-142
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8dd4
Q-score: 0.42
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ Pubmed: 36095215 DOI: doi:10.1073/pnas.2210769119 ]
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-142 bound (Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM Structure of p110alpha in complex with p85alpha
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 7myn
Q-score: 0.472
Liu X, Yang S, Hart JR, Xu Y, Zou X, Zhang H, Zhou Q, Xia T, Zhang Y, Yang D, Wang MW, Vogt PK
PNAS (2021) 118 [ Pubmed: 34725156 DOI: doi:10.1073/pnas.2109327118 ]
- Heterodimer of pik3ca with pik3r1 (200 kDa, Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)