Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7s0q
Q-score: 0.328
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ DOI: doi:10.1016/j.str.2022.05.007 Pubmed: 35660159 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor i (7 kDa, Protein from Homo sapiens)
- Beta-d-mannopyranose (180 Da, Ligand)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7s8v
Q-score: 0.232
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ DOI: doi:10.1016/j.str.2022.05.007 Pubmed: 35660159 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwg
Q-score: 0.453
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Insulin-like growth factor ii (Complex)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 6vwh
Q-score: 0.207
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Leg region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vwi
Q-score: 0.407
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the close-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Insulin-like growth factor ii (Complex)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
Resolution: 4.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwj
Q-score: 0.245
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Leg region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii (250 kDa, Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))