Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8iuk
Q-score: 0.45
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ Pubmed: 37160891 DOI: doi:10.1038/s41467-023-38411-x ]
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pgf2-alpha-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8iul
Q-score: 0.484
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ Pubmed: 37160891 DOI: doi:10.1038/s41467-023-38411-x ]
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Cryo-em structure of the latanoprost-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8ium
Q-score: 0.433
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ Pubmed: 37160891 DOI: doi:10.1038/s41467-023-38411-x ]
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Cryo-em structure of the tafluprost acid-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- (~{z})-7-[(1~{r},2~{r},3~{r},5~{s})-2-[(~{e})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid (410 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)