Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4(RXFP4)-Gi complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7yj4
Q-score: 0.429
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- G protein (Complex from Homo sapiens)
- Insulin-like peptide insl5 a chain (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Human relaxin family peptide receptor 4 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Insl5 (Complex from Homo sapiens)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with insl5 and g protein (Complex)
- Insulin-like peptide insl5 b chain (2 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7yk6
Q-score: 0.419
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1h-indol-3-yl)methylideneamino]guanidine (383 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with compound 4 and g protein (Complex)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7yk7
Q-score: 0.451
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with dc591053 and g protein (Complex)
- G protein (Complex from Bos taurus)
- [(1s)-7-ethoxy-6-methoxy-1-[2-(5-methoxy-1h-indol-3-yl)ethyl]-3,4-dihydro-1h-isoquinolin-2-yl]-morpholin-4-yl-methanone (493 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)