IAPP S20G lag-phase fibril polymorph 2PF-P
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8awt
Q-score: 0.603
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell (2023) 186 pp. 5798-5811.e26 [ DOI: doi:10.1016/j.cell.2023.11.025 Pubmed: 38134875 ]
IAPP S20G growth-phase fibril polymorph 2PF-L
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8az0
Q-score: 0.53
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell (2023) 186 pp. 5798-5811.e26 [ DOI: doi:10.1016/j.cell.2023.11.025 Pubmed: 38134875 ]
IAPP S20G growth-phase fibril polymorph 2PF-C
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8az1
Q-score: 0.546
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell (2023) 186 pp. 5798-5811.e26 [ DOI: doi:10.1016/j.cell.2023.11.025 Pubmed: 38134875 ]
IAPP S20G growth-phase fibril polymorph 3PF-CU
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8az2
Q-score: 0.515
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell (2023) 186 pp. 5798-5811.e26 [ DOI: doi:10.1016/j.cell.2023.11.025 Pubmed: 38134875 ]
IAPP S20G growth-phase fibril polymorph 4PF-CU
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8az3
Q-score: 0.491
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell (2023) 186 pp. 5798-5811.e26 [ DOI: doi:10.1016/j.cell.2023.11.025 Pubmed: 38134875 ]
IAPP S20G plateau-phase fibril polymorph 4PF-LU
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8az6
Q-score: 0.569
Wilkinson M, Xu Y, Thacker D, Taylor AIP, Fisher DG, Gallardo RU, Radford SE, Ranson NA
Cell (2023) 186 pp. 5798-5811.e26 [ DOI: doi:10.1016/j.cell.2023.11.025 Pubmed: 38134875 ]
Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bfa
Q-score: 0.539
Leistner C, Wilkinson M, Burgess A, Lovatt M, Goodbody S, Xu Y, Deuchars S, Radford SE, Ranson NA, Frank RAW
Nat Commun (2023) 14 pp. 2833-2833 [ DOI: doi:10.1038/s41467-023-38495-5 Pubmed: 37198197 ]
- Amyloid-beta precursor protein (4 kDa, Protein from Mus musculus)
- Sarkosyl-extracted appnl-g-f abeta42 fibril (4 MDa, Complex from Mus musculus)
Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bfb
Q-score: 0.581
Leistner C, Wilkinson M, Burgess A, Lovatt M, Goodbody S, Xu Y, Deuchars S, Radford SE, Ranson NA, Frank RAW
Nat Commun (2023) 14 pp. 2833-2833 [ DOI: doi:10.1038/s41467-023-38495-5 Pubmed: 37198197 ]
- Amyloid-beta precursor protein (4 kDa, Protein from Mus musculus)
- Sarkosyl-extracted appnl-g-f abeta42 fibril (4 MDa, Complex from Mus musculus)
Short chain dehydrogenase (SCR) cryoEM structure with NADP and ethyl 4-chloroacetoacetate
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7vyq
Q-score: 0.578
Li Y, Zhang R, Wang C, Forouhar F, Clarke OB, Vorobiev S, Singh S, Montelione GT, Szyperski T, Xu Y, Hunt JF
EMBO J (2022) 41 pp. e108368-e108368 [ DOI: doi:10.15252/embj.2021108368 Pubmed: 35801308 ]
- Ternary complex of scr with nadp and ethyl 4-chloroacetoacetate (Complex from Candida parapsilosis)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Carbonyl reductase (30 kDa, Protein from Candida parapsilosis)
- Ethyl 4-chloranyl-3-oxidanylidene-butanoate (164 Da, Ligand)