Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8gua
Q-score: 0.484
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2215621119-e2215621119 [ Pubmed: 36343266 DOI: doi:10.1073/pnas.2215621119 ]
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (441 Da, Ligand)
- Human pi3kalpha mutant e542k in complex with byl-719 (Complex from Homo sapiens)
Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8gub
Q-score: 0.531
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2215621119-e2215621119 [ Pubmed: 36343266 DOI: doi:10.1073/pnas.2215621119 ]
- Human pi3kalpha mutant h1047r in complex with byl-719 (Complex from Homo sapiens)
- (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (441 Da, Ligand)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8gud
Q-score: 0.44
Liu X, Zhou Q, Hart JR, Xu Y, Yang S, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2215621119-e2215621119 [ Pubmed: 36343266 DOI: doi:10.1073/pnas.2215621119 ]
- (2s)-n~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (441 Da, Ligand)
- Cryo-em structure of pi3kalpha mutant e545k in complex with byl-719 (Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
PI 3-kinase alpha with nanobody 3-126
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8dcp
Q-score: 0.584
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ Pubmed: 36095215 DOI: doi:10.1073/pnas.2210769119 ]
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-126 bound (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
PI 3-kinase alpha with nanobody 3-159
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8dcx
Q-score: 0.345
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ DOI: doi:10.1073/pnas.2210769119 Pubmed: 36095215 ]
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-159 bound (Complex from Homo sapiens)
PI 3-kinase alpha with nanobody 3-142
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8dd4
Q-score: 0.42
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ Pubmed: 36095215 DOI: doi:10.1073/pnas.2210769119 ]
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-142 bound (Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8dd8
Q-score: 0.454
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ DOI: doi:10.1073/pnas.2210769119 Pubmed: 36095215 ]
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-142 bound (Complex from Homo sapiens)