Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9l1s
Q-score: 0.459
Bai X, Xu L, Wang Z, Zhuang X, Ning J, Sun Y, Wang H, Guo Y, Xu Y, Guo J, Chen S, Pan L
To Be Published
- Pertuzumab fab heavy chain (24 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (70 kDa, Protein from Homo sapiens)
- Her2 (s310f) - pertuzumab (t30s/d31a) complex (Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)
Rat Kir4.1 in complex with PIP2
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5m
Q-score: 0.486
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ Pubmed: 38355723 DOI: doi:10.1038/s41589-024-01555-y ]
- Rat kir4.1 in complex with pip2 (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Rat Kir4.1 in complex with PIP2 and Lys05
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5n
Q-score: 0.414
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ Pubmed: 38355723 DOI: doi:10.1038/s41589-024-01555-y ]
- Rat kir4.1 in complex with pip2 and lys05 (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Acyl-ACP synthetase structure bound to MC7-ACP
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8i8d
Q-score: 0.555
Huang H, Wang C, Chang S, Cui T, Xu Y, Huang M, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 Pubmed: 39794554 ]
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Adenosine monophosphate (347 Da, Ligand)
- Acyl-acp synthetase bound to mc7-acp (Complex from Vibrio harveyi)
- 7-methoxy-7-oxidanylidene-heptanoic acid (174 Da, Ligand)
- N~3~-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-n-(2-sulfanylethyl)-beta-alaninamide (358 Da, Ligand)
- Acyl carrier protein (8 kDa, Protein from Escherichia coli)
Acyl-ACP synthetase structure bound to C18:1-ACP
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8i8e
Q-score: 0.524
Huang H, Wang C, Chang S, Cui T, Xu Y, Huang M, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 Pubmed: 39794554 ]
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Adenosine monophosphate (347 Da, Ligand)
- Acyl-acp synthetase bound to c18:1-acp (Complex from Vibrio harveyi)
- Acyl carrier protein (8 kDa, Protein from Escherichia coli)
- Oleic acid (282 Da, Ligand)
Acyl-ACP synthetase structure bound to AMP-C18:1
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8i6m
Q-score: 0.57
Huang H, Wang C, Chang S, Cui T, Xu Y, Huang M, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 Pubmed: 39794554 ]
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Magnesium ion (24 Da, Ligand)
- Adenosine monophosphate (347 Da, Ligand)
- Acyl-acp synthetase bound to amp-c18:1 (Complex from Vibrio harveyi)
- Oleic acid (282 Da, Ligand)
Acyl-ACP synthetase structure-2
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8hzx
Q-score: 0.55
Huang H, Wang C, Chang S, Cui T, Xu Y, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 ]
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Acyl-acp synthetase (Complex from Vibrio harveyi)
Acyl-ACP synthetase structure bound to oleic acid
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8i35
Q-score: 0.567
Huang H, Wang C, Chang S, Cui T, Xu Y, Huang M, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 Pubmed: 39794554 ]
- Acyl-acp synthetase bound to oleic acid (Complex from Vibrio harveyi)
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Oleic acid (282 Da, Ligand)
Acyl-ACP synthetase structure bound to AMP-PNP in the presence of MgCl2
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8i3i
Q-score: 0.6
Huang H, Wang C, Chang S, Cui T, Xu Y, Huang M, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 Pubmed: 39794554 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Magnesium ion (24 Da, Ligand)
- Acyl-acp synthetase bound to amp-pnp (Complex from Vibrio harveyi)
Acyl-ACP synthetase structure bound to ATP.
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8i49
Q-score: 0.596
Huang H, Wang C, Chang S, Cui T, Xu Y, Huang M, Zhang H, Zhou C, Zhang X, Feng Y
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01464-7 Pubmed: 39794554 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Acyl-acyl carrier protein synthetase (60 kDa, Protein from Vibrio harveyi)
- Acyl-acp synthetase bound to atp (Complex from Vibrio harveyi)