Cryo-EM structure of the BRS3-Gq complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8y51
Q-score: 0.399
To Be Published
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Brs3-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Bombesin receptor subtype-3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of the BA1-bound BRS3-Gq complex
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W
Cell Rep (2024) 43 pp. 114511-114511 [ DOI: doi:10.1016/j.celrep.2024.114511 Pubmed: 39024101 ]
- Ba1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Bombesin receptor subtype-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Ba1-brs3-gq complex (Complex from Homo sapiens)
Cryo-EM structure of the MK-5046-bound BRS3-Gq complex
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W
Cell Rep (2024) 43 pp. 114511-114511 [ DOI: doi:10.1016/j.celrep.2024.114511 Pubmed: 39024101 ]
- (2~{s})-1,1,1-tris(fluoranyl)-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1~{h}-imidazol-2-yl]propan-2-ol (444 Da, Ligand)
- Bombesin receptor subtype-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mk-5046-brs3-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Scfv16 (26 kDa, Protein from Mus musculus)
Structure of the NMB30-NMBR and Gq complex
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8h0p
Q-score: 0.405
Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W
Cell Res (2023) 33 pp. 184-187 [ DOI: doi:10.1038/s41422-022-00743-6 ]
- Nmb30 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuromedin-b receptor (43 kDa, Protein from Homo sapiens)
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Nmb30-nmbr-gq complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
Structure of the GRP14-27-GRPR-Gq complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8h0q
Q-score: 0.388
Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W
Cell Res (2023) 33 pp. 184-187 [ DOI: doi:10.1038/s41422-022-00743-6 ]
- Grp (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Grp-grpr-gq complex (160 MDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Gastrin-releasing peptide receptor (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8iuk
Q-score: 0.45
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ DOI: doi:10.1038/s41467-023-38411-x Pubmed: 37160891 ]
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pgf2-alpha-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
Cryo-EM structure of the latanoprost-bound human PTGFR-Gq complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8iul
Q-score: 0.484
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ DOI: doi:10.1038/s41467-023-38411-x Pubmed: 37160891 ]
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the latanoprost-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8ium
Q-score: 0.433
Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H
Nat Commun (2023) 14 pp. 2668-2668 [ DOI: doi:10.1038/s41467-023-38411-x Pubmed: 37160891 ]
- Prostaglandin f2-alpha receptor (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Cryo-em structure of the tafluprost acid-bound human ptgfr-gq complex (160 kDa, Complex from Homo sapiens)
- G subunit alpha (q) (41 kDa, Protein from Homo sapiens)
- (~{z})-7-[(1~{r},2~{r},3~{r},5~{s})-2-[(~{e})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid (410 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4(RXFP4)-Gi complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7yj4
Q-score: 0.429
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ DOI: doi:10.1038/s41467-023-36182-z Pubmed: 36717591 ]
- Insulin-like peptide insl5 a chain (2 kDa, Protein from Homo sapiens)
- Insulin-like peptide insl5 b chain (2 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with insl5 and g protein (Complex)
- Scfv16 (Complex from synthetic construct)
- Insl5 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Human relaxin family peptide receptor 4 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7yk6
Q-score: 0.419
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
- 1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1h-indol-3-yl)methylideneamino]guanidine (383 Da, Ligand)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with compound 4 and g protein (Complex)