Cryo-EM structure of the BRS3-Gq complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8y51
Q-score: 0.399
To Be Published
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Brs3-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Bombesin receptor subtype-3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xyd
Q-score: 0.366
Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y
Cell Rep (2024) 43 pp. 114422-114422 [ Pubmed: 38943642 DOI: doi:10.1016/j.celrep.2024.114422 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (2r)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ptafr-paf g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Platelet-activating factor receptor (39 kDa, Protein from Homo sapiens)
Human URAT1 bound to lesinurad
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9jdz
Q-score: 0.361
Wu C, Zhang C, Jin S, Wang JJ, Dai A, Xu J, Zhang H, Yang X, He X, Yuan Q, Hu W, Xu Y, Wang M, Jiang Y, Yang D, Xu HE
bioRxiv (2024) [ DOI: doi:10.1101/2024.09.11.612394 ]
- Lesinurad (404 Da, Ligand)
- Water (18 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Human uric acid transportor 1 with lesinurad (Complex from Homo sapiens)
Cryo-EM structure of the BA1-bound BRS3-Gq complex
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W
Cell Rep (2024) 43 pp. 114511-114511 [ DOI: doi:10.1016/j.celrep.2024.114511 Pubmed: 39024101 ]
- Ba1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Bombesin receptor subtype-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Ba1-brs3-gq complex (Complex from Homo sapiens)
Cryo-EM structure of the MK-5046-bound BRS3-Gq complex
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W
Cell Rep (2024) 43 pp. 114511-114511 [ DOI: doi:10.1016/j.celrep.2024.114511 Pubmed: 39024101 ]
- (2~{s})-1,1,1-tris(fluoranyl)-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1~{h}-imidazol-2-yl]propan-2-ol (444 Da, Ligand)
- Bombesin receptor subtype-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mk-5046-brs3-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Scfv16 (26 kDa, Protein from Mus musculus)
Structure of nanobody-bound DRD1_LSD complex
Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S
Neuron (2024) 112 pp. 3295- [ DOI: doi:10.1016/j.neuron.2024.07.003 Pubmed: 39094559 ]
- Fab 8d3 (Complex from Mus musculus)
- Prac-prad-prg (Complex from Escherichia coli O157:H7)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- Drd1 (Complex from Homo sapiens)
- Nanobody-bound drd1_lsd complex (170 kDa, Complex)
- Nba3 (13 kDa, Protein from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (60 kDa, Protein from Streptococcus sp. 'group G')
- Fab 8d3 light chain (26 kDa, Protein from Mus musculus)
- Fab 8d3 heavy chain (27 kDa, Protein from Mus musculus)
- D(1a) dopamine receptor (39 kDa, Protein from Homo sapiens)
Structure of nanobody-bound DRD1_PF-6142 complex
Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S
Neuron (2024) 112 pp. 3295- [ DOI: doi:10.1016/j.neuron.2024.07.003 Pubmed: 39094559 ]
- 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine (356 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (60 kDa, Protein from Staphylococcus aureus)
- Nanobody-bound drd1_pf-6142 complex (170 kDa, Complex)
- Drd1 (Complex from Homo sapiens)
- Prac-prad-prg (Complex from Escherichia coli)
- Nba3 (13 kDa, Protein from Homo sapiens)
- Fab 8d3 light chain (26 kDa, Protein from Mus musculus)
- Fab 8d3 heavy chain (27 kDa, Protein from Mus musculus)
- D(1a) dopamine receptor (39 kDa, Protein from Homo sapiens)
- Fab (Complex from Mus musculus)
Structure of L797591-SSTR1 G protein complex
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xio
Q-score: 0.469
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- L797591-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- G-alpha-i (41 kDa, Protein from Homo sapiens)
- (2~{s})-~{n}-[(4~{s})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide (607 Da, Ligand)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
Structure of Pasireotide-SSTR1 G protein complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xip
Q-score: 0.384
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- 004-dtr-lys-ty5-phe-a1d5e (1 kDa, Protein from synthetic construct)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Pasireotide-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
Structure of L796778-SSTR3 G protein complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8xiq
Q-score: 0.462
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nit-fc0-nle-a1d5b (584 Da, Protein from synthetic construct)
- Water (18 Da, Ligand)
- Somatostatin receptor type 3 (40 kDa, Protein from Homo sapiens)
- Structure of l796778-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)