Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9l1s
Q-score: 0.459
Bai X, Xu L, Wang Z, Zhuang X, Ning J, Sun Y, Wang H, Guo Y, Xu Y, Guo J, Chen S, Pan L
To Be Published
- Pertuzumab fab heavy chain (24 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (70 kDa, Protein from Homo sapiens)
- Her2 (s310f) - pertuzumab (t30s/d31a) complex (Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2 Coupled to G Protein
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8xxu
Q-score: 0.432
To Be Published
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Pd2r2-g protein (Complex from Homo sapiens)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8xxv
Q-score: 0.479
To Be Published
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Pd2r2-indomethacin-g protein (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 9iyb
Q-score: 0.475
To Be Published
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Prostaglandin d2 receptor 2-pgd2-g protein complex (160 kDa, Complex from Homo sapiens)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (43 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9e6k
Q-score: 0.473
Saha N, Lee SG, Brockmann EC, de la Cruz MJ, Goldgur Y, Mendoza RP, Stanchina E, Love TM, Marvald J, Xu Y, Xu K, Himanen JP, Lamminmaki U, Veach D, Nikolov DB
Biomed Pharmacother (2024) 180 pp. 117605-117605 [ Pubmed: 39461016 DOI: doi:10.1016/j.biopha.2024.117605 ]
- Light chain monoclonal antibody c12 (23 kDa, Protein from Homo sapiens)
- Complex of adam17 disintegrin-cysteine rich domain (Complex from Homo sapiens)
- Heavy chain of monoclonal antibody c12 (23 kDa, Protein from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (12 kDa, Protein from Homo sapiens)
MPOX E5 hexamer AMP-PNP and ssDNA bound form with clear primase domain
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8wgy
Q-score: 0.494
Xu Y, Wu Y, Zhang Y, Gao K, Wu X, Yang Y, Li D, Yang B, Zhang Z, Dong C
Sci Adv (2024) 10 pp. eadl1150-eadl1150 [ DOI: doi:10.1126/sciadv.adl1150 Pubmed: 39167653 ]
- Mpox helicase (Complex from Monkeypox virus)
- Uncoating factor opg117 (90 kDa, Protein from Monkeypox virus)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*cp*cp*c)-3') (822 Da, DNA from Spodoptera frugiperda)
- Zinc ion (65 Da, Ligand)
MPOX E5 double hexamer ssDNA bound conformation
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8wgz
Q-score: 0.273
Xu Y, Wu Y, Zhang Y, Gao K, Wu X, Yang Y, Li D, Yang B, Zhang Z, Dong C
Sci Adv (2024) 10 pp. eadl1150-eadl1150 [ DOI: doi:10.1126/sciadv.adl1150 Pubmed: 39167653 ]
- Dna (5'-d(p*cp*cp*cp*cp*c)-3') (1 kDa, DNA from Spodoptera frugiperda)
- Mpox helicase (Complex from Monkeypox virus)
- Uncoating factor opg117 (90 kDa, Protein from Monkeypox virus)
Structure of the Position 1 to 3 Open gamma-Tubulin Ring Complex from Pig Brain
Xu Y, Munoz-Hernandez H, Krutyholowa R, Marxer F, Cetin F, Wieczorek M
Dev Cell (2024) 59 pp. 3161-3174.e15 [ Pubmed: 39321808 DOI: doi:10.1016/j.devcel.2024.09.002 ]
Structure of the Position 4 to 11 Open gamma-Tubulin Ring Complex from Pig Brain
Xu Y, Munoz-Hernandez H, Krutyholowa R, Marxer F, Cetin F, Wieczorek M
Dev Cell (2024) 59 pp. 3161-3174.e15 [ Pubmed: 39321808 DOI: doi:10.1016/j.devcel.2024.09.002 ]
Structure of the Position 10 to 12 Open gamma-Tubulin Ring Complex from Pig Brain
Xu Y, Munoz-Hernandez H, Krutyholowa R, Marxer F, Cetin F, Wieczorek M
Dev Cell (2024) 59 pp. 3161-3174.e15 [ Pubmed: 39321808 DOI: doi:10.1016/j.devcel.2024.09.002 ]