Resolution: 2.37 Å
EM Method: Single-particle
Fitted PDBs: 8yak
Q-score: 0.652
Hu Y, Dai L, Xu Y, Niu D, Yang X, Xie Z, Shen P, Li X, Li H, Zhang L, Min J, Guo RT, Chen CC
Int J Biol Macromol (2024) 278 pp. 134831-134831 [ DOI: doi:10.1016/j.ijbiomac.2024.134831 Pubmed: 39163957 ]
- (2~{s})-2-[[(3~{r})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid (403 Da, Ligand)
- Imidazolonepropionase (43 kDa, Protein from Pseudoxanthomonas wuyuanensis)
- Zinc ion (65 Da, Ligand)
- Pwadh-g88d-d344n (Complex from Pseudoxanthomonas wuyuanensis)
Cryo-electron microscopic structure of an amide hydrolase from Pseudoxanthomonas wuyuanensis
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8yag
Q-score: 0.665
Hu Y, Dai L, Xu Y, Niu D, Yang X, Xie Z, Shen P, Li X, Li H, Zhang L, Min J, Guo RT, Chen CC
Int J Biol Macromol (2024) 278 pp. 134831-134831 [ DOI: doi:10.1016/j.ijbiomac.2024.134831 Pubmed: 39163957 ]
- Zinc ion (65 Da, Ligand)
- Imidazolonepropionase (43 kDa, Protein from Pseudoxanthomonas wuyuanensis)
- Pwadh (Complex from Pseudoxanthomonas wuyuanensis)
Structure of nanobody-bound DRD1_LSD complex
Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S
Neuron (2024) 112 pp. 3295- [ DOI: doi:10.1016/j.neuron.2024.07.003 Pubmed: 39094559 ]
- D(1a) dopamine receptor (39 kDa, Protein from Homo sapiens)
- Prac-prad-prg (Complex from Escherichia coli O157:H7)
- Fab 8d3 heavy chain (27 kDa, Protein from Mus musculus)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- Drd1 (Complex from Homo sapiens)
- Nanobody-bound drd1_lsd complex (170 kDa, Complex)
- Fab 8d3 (Complex from Mus musculus)
- Maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (60 kDa, Protein from Streptococcus sp. 'group G')
- Nba3 (13 kDa, Protein from Homo sapiens)
- Fab 8d3 light chain (26 kDa, Protein from Mus musculus)
Structure of nanobody-bound DRD1_PF-6142 complex
Fan L, Zhuang Y, Wu H, Li H, Xu Y, Wang Y, He L, Wang S, Chen Z, Cheng J, Xu HE, Wang S
Neuron (2024) 112 pp. 3295- [ DOI: doi:10.1016/j.neuron.2024.07.003 Pubmed: 39094559 ]
- 4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine (356 Da, Ligand)
- D(1a) dopamine receptor (39 kDa, Protein from Homo sapiens)
- Fab 8d3 heavy chain (27 kDa, Protein from Mus musculus)
- Prac-prad-prg (Complex from Escherichia coli)
- Drd1 (Complex from Homo sapiens)
- Fab (Complex from Mus musculus)
- Nanobody-bound drd1_pf-6142 complex (170 kDa, Complex)
- Maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (60 kDa, Protein from Staphylococcus aureus)
- Nba3 (13 kDa, Protein from Homo sapiens)
- Fab 8d3 light chain (26 kDa, Protein from Mus musculus)
Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8itl
Q-score: 0.477
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW
PNAS (2023) 120 pp. e2306145120-e2306145120 [ DOI: doi:10.1073/pnas.2306145120 Pubmed: 37792509 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of a splice variant of the gipr(sv1) in complex with gs protein (Complex from Homo sapiens)
- Gastric inhibitory polypeptide receptor (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8itm
Q-score: 0.479
Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW
PNAS (2023) 120 pp. e2306145120-e2306145120 [ DOI: doi:10.1073/pnas.2306145120 Pubmed: 37792509 ]
- Cryo-em structure of a splice variant of the gipr(sv2) in complex with gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide receptor (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8inr
Q-score: 0.49
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ Pubmed: 37524700 DOI: doi:10.1107/S0907444909042073 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cryo-em structure of alpha-msh-bound human melanocortin receptor 5 in complex with g protein (Complex from Homo sapiens)
- Ha signal peptide,melanocortin receptor 5,lgbit subunit (56 kDa, Protein from Homo sapiens)
- Alpha-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8ioc
Q-score: 0.459
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ Pubmed: 37524700 DOI: doi:10.1107/S0907444909042073 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Gamma-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Nanobody-35 (17 kDa, Protein from Homo sapiens)
- Cryo-em structure of gamma-msh-bound human melanocortin receptor 3 in complex with g protein (Complex from Homo sapiens)
- Ha signal peptide,melanocortin receptor 3,lgbit subunit (56 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8iod
Q-score: 0.503
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ Pubmed: 37524700 DOI: doi:10.1107/S0907444909042073 ]
- Cryo-em structure of pg-901-bound human melanocortin receptor 5 in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Pg-901 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Nanobody-35 (17 kDa, Protein from Homo sapiens)
- Ha signal peptide,melanocortin receptor 5,lgbit subunit (56 kDa, Protein from Homo sapiens)
Cryo-EM structure of the erythromycin-bound motilin receptor-Gq protein complex
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8ibu
Q-score: 0.394
You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y
Sci Adv (2023) 9 pp. eade9020-eade9020 [ DOI: doi:10.1126/sciadv.ade9020 Pubmed: 36921049 ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,motilin receptor,fusion tag (81 kDa, Protein from Homo sapiens)
- Erythromycin-bound motilin receptor-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Erythromycin a (733 Da, Ligand)