XBB.1.5.10 RBD in complex with ACE2
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8wtd
Q-score: 0.508
Jian F, Feng L, Yang S, Yu Y, Wang L, Song W, Yisimayi A, Chen X, Xu Y, Wang P, Yu L, Wang J, Liu L, Niu X, Wang J, Xiao T, An R, Wang Y, Gu Q, Shao F, Jin R, Shen Z, Wang Y, Wang X, Cao Y
PLoS Pathog (2023) 19 pp. e1011868-e1011868 [ DOI: doi:10.1371/journal.ppat.1011868 Pubmed: 38117863 ]
- Spike protein s2' (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rbd in complex with ace2 (Complex)
- Human ace2 (Complex from Homo sapiens)
- Xbb.1.5 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
XBB.1.5.70 spike protein in complex with ACE2
Resolution: 4.64 Å
EM Method: Single-particle
Fitted PDBs: 8wtj
Q-score: 0.202
Jian F, Feng L, Yang S, Yu Y, Wang L, Song W, Yisimayi A, Chen X, Xu Y, Wang P, Yu L, Wang J, Liu L, Niu X, Wang J, Xiao T, An R, Wang Y, Gu Q, Shao F, Jin R, Shen Z, Wang Y, Wang X, Cao Y
PLoS Pathog (2023) 19 pp. e1011868-e1011868 [ DOI: doi:10.1371/journal.ppat.1011868 Pubmed: 38117863 ]
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Homo sapiens)
- Human ace2 (Complex from Homo sapiens)
- Spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (145 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Xbb.1.5.70 spike protein in complex with hace2 (Complex)
XBB.1.5 spike protein in complex with ACE2
Resolution: 4.34 Å
EM Method: Single-particle
Fitted PDBs: 8wrm
Q-score: 0.219
Jian F, Feng L, Yang S, Yu Y, Wang L, Song W, Yisimayi A, Chen X, Xu Y, Wang P, Yu L, Wang J, Liu L, Niu X, Wang J, Xiao T, An R, Wang Y, Gu Q, Shao F, Jin R, Shen Z, Wang Y, Wang X, Cao Y
PLoS Pathog (2023) 19 pp. e1011868-e1011868 [ DOI: doi:10.1371/journal.ppat.1011868 Pubmed: 38117863 ]
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Homo sapiens)
- Hace2 (Complex from Homo sapiens)
- Xbb.1.5 spike protein in complex with hace2 (Complex)
- Spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (135 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
XBB.1.5.10 spike protein in complex with ACE2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8wro
Q-score: 0.193
Jian F, Feng L, Yang S, Yu Y, Wang L, Song W, Yisimayi A, Chen X, Xu Y, Wang P, Yu L, Wang J, Liu L, Niu X, Wang J, Xiao T, An R, Wang Y, Gu Q, Shao F, Jin R, Shen Z, Wang Y, Wang X, Cao Y
PLoS Pathog (2023) 19 pp. e1011868-e1011868 [ DOI: doi:10.1371/journal.ppat.1011868 Pubmed: 38117863 ]
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Homo sapiens)
- Human ace2 (Complex from Homo sapiens)
- Spike glycoprotein,spike glycoprotein,spike glycoprotein,fusion protein (145 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Xbb.1.5.10 spike protein in complex with ace2 (Complex)
- Spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 XBB.1.5.70 in complex with ACE2
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8wrh
Q-score: 0.497
Jian F, Feng L, Yang S, Yu Y, Wang L, Song W, Yisimayi A, Chen X, Xu Y, Wang P, Yu L, Wang J, Liu L, Niu X, Wang J, Xiao T, An R, Wang Y, Gu Q, Shao F, Jin R, Shen Z, Wang Y, Wang X, Cao Y
PLoS Pathog (2023) 19 pp. e1011868-e1011868 [ DOI: doi:10.1371/journal.ppat.1011868 Pubmed: 38117863 ]
- Sars-cov-2 xbb.1.5.70 in complex with ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ace2 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Xbb.1.5.70 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (92 kDa, Protein from Homo sapiens)
XBB.1.5 RBD in complex with ACE2
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8wrl
Q-score: 0.454
Jian F, Feng L, Yang S, Yu Y, Wang L, Song W, Yisimayi A, Chen X, Xu Y, Wang P, Yu L, Wang J, Liu L, Niu X, Wang J, Xiao T, An R, Wang Y, Gu Q, Shao F, Jin R, Shen Z, Wang Y, Wang X, Cao Y
PLoS Pathog (2023) 19 pp. e1011868-e1011868 [ DOI: doi:10.1371/journal.ppat.1011868 Pubmed: 38117863 ]
- Spike protein s1 (26 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Homo sapiens)
- Human ace2 (Complex from Homo sapiens)
- Sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Xbb.1.5 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4(RXFP4)-Gi complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7yj4
Q-score: 0.429
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ DOI: doi:10.1038/s41467-023-36182-z Pubmed: 36717591 ]
- Insulin-like peptide insl5 a chain (2 kDa, Protein from Homo sapiens)
- Insulin-like peptide insl5 b chain (2 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with insl5 and g protein (Complex)
- Scfv16 (Complex from synthetic construct)
- Insl5 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Human relaxin family peptide receptor 4 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7yk6
Q-score: 0.419
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
- 1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1h-indol-3-yl)methylideneamino]guanidine (383 Da, Ligand)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with compound 4 and g protein (Complex)
Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7yk7
Q-score: 0.451
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with dc591053 and g protein (Complex)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- G protein (Complex from Bos taurus)
- [(1s)-7-ethoxy-6-methoxy-1-[2-(5-methoxy-1h-indol-3-yl)ethyl]-3,4-dihydro-1h-isoquinolin-2-yl]-morpholin-4-yl-methanone (493 Da, Ligand)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
An Agonist and PAM-bound Class A GPCR with Gi protein complex structure
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7v68
Q-score: 0.334
Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T
Nat Commun (2022) 13 pp. 2855-2855 [ DOI: doi:10.1038/s41467-022-30595-y Pubmed: 35606397 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m4 (39 kDa, Protein from Homo sapiens)
- Gi complex (Complex from Homo sapiens)
- M4r_iperoxo_ly2119620_gi complex (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m4r (Complex)
- 3-amino-5-chloro-n-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide (437 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-n,n,n-trimethylbut-2-yn-1-aminium (197 Da, Ligand)
- Scfv16 (27 kDa, Protein from Homo sapiens)