cryo-EM structure of Staphylococcus aureus(ATCC 29213) 50S ribosome in complex with MCX-190.
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8y36
Q-score: 0.58
Ma CX, Li Y, Liu WT, Li Y, Zhao F, Lian XT, Ding J, Liu SM, Liu XP, Fan BZ, Liu LY, Xue F, Li J, Zhang JR, Xue Z, Pei XT, Lin JZ, Liang JH
Cell Discov (2024) 10 pp. 75-75 [ DOI: doi:10.1038/s41421-024-00702-y Pubmed: 38992047 ]
- Large ribosomal subunit protein bl32 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl35 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl36 (4 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul5 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul30 (6 kDa, Protein from Staphylococcus aureus)
- 7-[4-[3-[[(1~{s},2~{r},5~{r},6~{s},7~{s},8~{r},9~{r},11~{r},13~{r},14~{r})-8-[(2~{s},3~{r},4~{s},6~{r})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid (969 Da, Ligand)
- Large ribosomal subunit protein ul3 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul4 (22 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul14 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul15 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl17 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul13 (16 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl33b (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl21 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul2 (29 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl19 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl28 (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl25 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl20 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul29 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl34 (5 kDa, Protein from Staphylococcus aureus)
- Water (18 Da, Ligand)
- Large ribosomal subunit protein ul24 (11 kDa, Protein from Staphylococcus aureus)
- 5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus)
- Staphylococcus aureus(atcc 29213) 50s ribosome in complex with mcx-190. (Complex from Staphylococcus aureus)
- Magnesium ion (24 Da, Ligand)
- Large ribosomal subunit protein ul16 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl27 (8 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul23 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul6 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl31b (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul22 (12 kDa, Protein from Staphylococcus aureus)
- 23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein ul18 (13 kDa, Protein from Staphylococcus aureus)
Cryo-EM structure of Staphylococcus aureus (15B196) 50S ribosome in complex with MCX-190.
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8y37
Q-score: 0.534
Ma CX, Li Y, Liu WT, Li Y, Zhao F, Lian XT, Ding J, Liu SM, Liu XP, Fan BZ, Liu LY, Xue F, Li J, Zhang JR, Xue Z, Pei XT, Lin JZ, Liang JH
Cell Discov (2024) 10 pp. 75-75 [ DOI: doi:10.1038/s41421-024-00702-y Pubmed: 38992047 ]
- Large ribosomal subunit protein bl21 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul16 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul23 (10 kDa, Protein from Staphylococcus aureus)
- Staphylococcus aureus(15b196) 50s ribosome in complex with mcx-190. (Complex from Staphylococcus aureus)
- Large ribosomal subunit protein bl28 (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul15 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul29 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl36 (4 kDa, Protein from Staphylococcus aureus)
- Water (18 Da, Ligand)
- Large ribosomal subunit protein ul13 (16 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul22 (12 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl27 (8 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul30 (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul5 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl17 (13 kDa, Protein from Staphylococcus aureus)
- 7-[4-[3-[[(1~{s},2~{r},5~{r},6~{s},7~{s},8~{r},9~{r},11~{r},13~{r},14~{r})-8-[(2~{s},3~{r},4~{s},6~{r})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid (969 Da, Ligand)
- Large ribosomal subunit protein bl32 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul4 (22 kDa, Protein from Staphylococcus aureus)
- 23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein ul14 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul24 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul18 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul6 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl35 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl19 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl31b (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul3 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl34 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl33b (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl20 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul2 (29 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl25 (10 kDa, Protein from Staphylococcus aureus)
- 5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190.
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8y38
Q-score: 0.537
Ma CX, Li Y, Liu WT, Li Y, Zhao F, Lian XT, Ding J, Liu SM, Liu XP, Fan BZ, Liu LY, Xue F, Li J, Zhang JR, Xue Z, Pei XT, Lin JZ, Liang JH
Cell Discov (2024) 10 pp. 75-75 [ DOI: doi:10.1038/s41421-024-00702-y Pubmed: 38992047 ]
- Small ribosomal subunit protein us10 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl32 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl35 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl36 (4 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul5 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul30 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us3 (24 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul3 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul4 (22 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs6 (11 kDa, Protein from Staphylococcus aureus)
- 7-[4-[3-[[(1~{s},2~{r},5~{r},6~{s},7~{s},8~{r},9~{r},11~{r},13~{r},14~{r})-8-[(2~{s},3~{r},4~{s},6~{r})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid (969 Da, Ligand)
- Large ribosomal subunit protein ul14 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul15 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl17 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul13 (16 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs20 (9 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl33b (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl21 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul2 (29 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl19 (13 kDa, Protein from Staphylococcus aureus)
- 23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein bl28 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl25 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl20 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul29 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl34 (5 kDa, Protein from Staphylococcus aureus)
- Water (18 Da, Ligand)
- Large ribosomal subunit protein ul24 (11 kDa, Protein from Staphylococcus aureus)
- 5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus)
- Small ribosomal subunit protein us7 (17 kDa, Protein from Staphylococcus aureus)
- Staphylococcus aureus 70s ribosome (strain 15b196) in complex with mcx-190. (Complex from Staphylococcus aureus)
- Magnesium ion (24 Da, Ligand)
- 16s ribosomal rna (500 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein ul16 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl27 (8 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul23 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul6 (19 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us13 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs16 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl31b (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul22 (12 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us9 (14 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us17 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us2 (26 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us14b (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul18 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us12 (16 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us19 (12 kDa, Protein from Staphylococcus aureus)
cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8y39
Q-score: 0.353
Ma CX, Li Y, Liu WT, Li Y, Zhao F, Lian XT, Ding J, Liu SM, Liu XP, Fan BZ, Liu LY, Xue F, Li J, Zhang JR, Xue Z, Pei XT, Lin JZ, Liang JH
Cell Discov (2024) 10 pp. 75-75 [ DOI: doi:10.1038/s41421-024-00702-y Pubmed: 38992047 ]
- Large ribosomal subunit protein bl21 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul16 (15 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul23 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl28 (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs20 (9 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul15 (15 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us9 (14 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul29 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl36 (4 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us7 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul13 (16 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us13 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us17 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul22 (12 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us14b (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl27 (8 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul30 (6 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul5 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl17 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us12 (16 kDa, Protein from Staphylococcus aureus)
- 7-[4-[3-[[(1~{s},2~{r},5~{r},6~{s},7~{s},8~{r},9~{r},11~{r},13~{r},14~{r})-8-[(2~{s},3~{r},4~{s},6~{r})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid (969 Da, Ligand)
- Large ribosomal subunit protein bl32 (5 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul4 (22 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs6 (11 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us10 (11 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul14 (13 kDa, Protein from Staphylococcus aureus)
- 23s ribosomal rna (946 kDa, RNA from Staphylococcus aureus)
- Large ribosomal subunit protein ul24 (11 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us15 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul18 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs16 (10 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul6 (19 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl35 (7 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl19 (13 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us4 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl31b (6 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us11 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul3 (23 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl34 (5 kDa, Protein from Staphylococcus aureus)
- 16s ribosomal rna (500 kDa, RNA from Staphylococcus aureus)
- Small ribosomal subunit protein us2 (26 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us8 (14 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl33b (5 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein us5 (17 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl20 (13 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein ul2 (29 kDa, Protein from Staphylococcus aureus)
- Large ribosomal subunit protein bl25 (10 kDa, Protein from Staphylococcus aureus)
- Small ribosomal subunit protein bs18 (9 kDa, Protein from Staphylococcus aureus)
- 5s ribosomal rna (36 kDa, RNA from Staphylococcus aureus)
- Small ribosomal subunit protein us19 (12 kDa, Protein from Staphylococcus aureus)
- Magnesium ion (24 Da, Ligand)
- Small ribosomal subunit protein us3 (24 kDa, Protein from Staphylococcus aureus)
- Staphylococcus aureus(atcc 29213) 70s ribosome in complex with mcx-190. (Complex from Staphylococcus aureus)