mouse proteasome 20S subunit in complex with compound 1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8ypk
Q-score: 0.621
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-7 (25 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Mus musculus)
- 20s proteasome (Complex from Mus musculus)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Mus musculus)
- [(1r)-1-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]-3-methyl-butyl]boronic acid (308 Da, Ligand)
- Proteasome subunit beta type-6 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-5 (22 kDa, Protein from Mus musculus)
canine immunoproteasome 20S subunit in complex with compound 2
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8ysx
Q-score: 0.541
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Proteasome subunit beta type-8 (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- [(~{r})-cyclohexyl-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]methyl]boronic acid (334 Da, Ligand)
- Proteasome subunit beta (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (24 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (23 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (28 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (21 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (25 kDa, Protein from Canis lupus familiaris)
- Water (18 Da, Ligand)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- 20s immunoproteasome (Complex from Canis lupus familiaris)
canine immunoproteasome 20S subunit in complex with compound 1
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8yvg
Q-score: 0.707
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Proteasome subunit beta type-8 (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- [(1r)-1-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]-3-methyl-butyl]boronic acid (308 Da, Ligand)
- Proteasome subunit beta (21 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (29 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (27 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (26 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (22 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (28 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit beta (23 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (25 kDa, Protein from Canis lupus familiaris)
- Proteasome subunit alpha type (29 kDa, Protein from Canis lupus familiaris)
- 20s immunoproteasome (Complex from Canis lupus familiaris)
canine immunoproteasome 20S subunit in complex with compound 1
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8yvp
Q-score: 0.64
Arai Y, Shitama H, Yamagishi M, Ono S, Kashima A, Hiraizumi M, Tsuda N, Katayama K, Tanaka K, Koda Y, Kato S, Sakata K, Nureki O, Miyazaki H
Bioorg.Med.Chem. (2024) 109 pp. 117790-117790 [ Pubmed: 38906067 DOI: doi:10.1016/j.bmc.2024.117790 ]
- Threonine (119 Da, Ligand)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-7 (25 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-2 (22 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-3 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Mus musculus)
- 20s proteasome (Complex from Mus musculus)
- [(~{r})-cyclohexyl-[(1-cyclohexyl-1,2,3-triazol-4-yl)carbonylamino]methyl]boronic acid (334 Da, Ligand)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-6 (22 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-1 (26 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Mus musculus)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-4 (29 kDa, Protein from Mus musculus)
- Proteasome subunit beta type-5 (22 kDa, Protein from Mus musculus)
Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the AMPPNP state
Resolution: 6.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 5hnw
Q-score: 0.139
Yamagishi M, Shigematsu H, Yokoyama T, Kikkawa M, Sugawa M, Aoki M, Shirouzu M, Yajima J, Nitta R
Structure (2016) 24 pp. 1322-1334 [ DOI: doi:10.1016/j.str.2016.05.021 Pubmed: 27452403 ]
Resolution: 6.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 5hnx
Q-score: 0.138
Yamagishi M, Shigematsu H, Yokoyama T, Kikkawa M, Sugawa M, Aoki M, Shirouzu M, Yajima J, Nitta R
Structure (2016) 24 pp. 1322-1334 [ DOI: doi:10.1016/j.str.2016.05.021 Pubmed: 27452403 ]
- Tubulin alpha-1b chain (50 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Taxol (853 Da, Ligand)
- Tubulin beta-2b chain (Complex from Bos taurus)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Tubulin beta-2b chain (49 kDa, Protein from Bos taurus)
- Minus-end directed ncd chimera nkn664 in the amppnp state complexed with gdp-taxol microtubule (Complex)
- Protein claret segregational,kinesin-1/kinesin-14,protein claret segregational (Complex)
- Tubulin alpha-1b chain (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Protein claret segregational,kinesin-1/kinesin-14,protein claret segregational (41 kDa, Protein from Drosophila melanogaster)
Structural basis of backwards motion in kinesin-14: plus-end directed nKn669 in the AMPPNP state
Resolution: 6.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 5hny
Q-score: 0.145
Yamagishi M, Shigematsu H, Yokoyama T, Kikkawa M, Sugawa M, Aoki M, Shirouzu M, Yajima J, Nitta R
Structure (2016) 24 pp. 1322-1334 [ DOI: doi:10.1016/j.str.2016.05.021 Pubmed: 27452403 ]
- Tubulin alpha-1b chain (Complex)
- Tubulin beta-2b chain (47 kDa, Protein from Bos taurus)
- Tubulin beta-2b chain (Complex)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Protein claret segregational, kinesin-1/kinesin-14, protein claret segregational (41 kDa, Protein from Drosophila melanogaster)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Tubulin alpha-1b chain (48 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Plus-end directed ncd chimera nkn669 in the amppnp state complexed with gdp-taxol microtubule (Complex)
- Protein claret segregational,plus-end directed kinesin-1/kinesin-14,protein claret segregational (Complex)
- Taxol (853 Da, Ligand)
Resolution: 5.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 5hnz
Q-score: 0.144
Yamagishi M, Shigematsu H, Yokoyama T, Kikkawa M, Sugawa M, Aoki M, Shirouzu M, Yajima J, Nitta R
Structure (2016) 24 pp. 1322-1334 [ DOI: doi:10.1016/j.str.2016.05.021 Pubmed: 27452403 ]
- Tubulin alpha-1b chain (50 kDa, Protein from Bos taurus)
- Tubulin alpha-1b chain (Complex)
- Tubulin beta-2b chain (Complex)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Protein claret segregational,protein claret segregational,plus-end directed kinesin-1/kinesin-14,protein claret segregational,protein claret segregational (41 kDa, Protein from Drosophila melanogaster)
- Tubulin beta-2b chain (49 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Plus-end directed ncd chimera nkn669 in the nucleotide-free state complexed with gdp-taxol microtubule (Complex)
- Protein claret segregational,plus-end directed kinesin-1/kinesin-14,protein claret segregational (Complex)
- Taxol (853 Da, Ligand)