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primary_citation_author:"Yan RH" AND xref_links:"drugbank" AND xref_links:"alphafold"
Structure of y+LAT1 bound with Leu
Release date: Jan. 22, 2025
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xxi
Q-score: 0.55
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8xxi
Q-score: 0.55
To Be Published
Sample:
- Sodium ion (22 Da, Ligand)
- Structure of the y+lat1 bound with leu (Complex from Homo sapiens)
- Leucine (131 Da, Ligand)
- Y+l amino acid transporter 1 (57 kDa, Protein from Homo sapiens)
Overall structure of the LAT1-4F2hc bound with Leu
Release date: Nov. 13, 2024
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8x0w
Q-score: 0.422
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8x0w
Q-score: 0.422
To Be Published
Sample:
- Large neutral amino acids transporter small subunit 1 (50 kDa, Protein from Homo sapiens)
- Leucine (131 Da, Ligand)
- Amino acid transporter heavy chain slc3a2 (51 kDa, Protein from Homo sapiens)
- Overall structure of the lat1-4f2hc bound with leu (Complex from Homo sapiens)
Overall structure of the LAT1-4F2hc bound with L-dopa
Release date: July 17, 2024
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8j8l
Q-score: 0.371
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8j8l
Q-score: 0.371
To Be Published
Sample:
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- 3,4-dihydroxyphenylalanine (197 Da, Ligand)
- Overall structure of the lat1-4f2hc bound with l-dopa (Complex from Homo sapiens)
Overall structure of the LAT1-4F2hc bound with tyrosine
Release date: July 10, 2024
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ida
Q-score: 0.514
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ida
Q-score: 0.514
To Be Published
Sample:
- Overall structure of the lat1-4f2hc bound with tyrosine (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Tyrosine (181 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
Overall structure of the LAT1-4F2hc bound with tryptophan
Release date: July 10, 2024
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8j8m
Q-score: 0.378
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8j8m
Q-score: 0.378
To Be Published
Sample:
- Large neutral amino acids transporter small subunit 1 (57 kDa, Protein from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Overall structure of the lat1-4f2hc bound with tryptophan (Complex from Homo sapiens)