Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7xni
Q-score: 0.315
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ DOI: doi:10.1073/pnas.2207067119 Pubmed: 36763058 ]
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Kcnq1-cam complex (Cellular component from Homo sapiens)
human KCNQ1-CaM in complex with ML277
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7xnk
Q-score: 0.467
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ DOI: doi:10.1073/pnas.2207067119 Pubmed: 36763058 ]
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- Kcnq1-cam in complex with ml277 (Cellular component from Homo sapiens)
- Potassium ion (39 Da, Ligand)
human KCNQ1-CaM-ML277-PIP2 complex in state A
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xnl
Q-score: 0.412
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ DOI: doi:10.1073/pnas.2207067119 Pubmed: 36763058 ]
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Human kcnq1-cam-ml277-pip2 complex in state a (Cellular component from Homo sapiens)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Potassium ion (39 Da, Ligand)
human KCNQ1-CaM-ML277-PIP2 complex in state B
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7xnn
Q-score: 0.428
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ DOI: doi:10.1073/pnas.2207067119 Pubmed: 36763058 ]
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
- Human kcnq1-cam-ml277-pip2 complex in state b (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Potassium ion (39 Da, Ligand)