SLC19A3-Thiamine inward structure
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8z7x
Q-score: 0.443
SLC19A3-Fedratinib inward structure
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8z7y
Q-score: 0.484
SLC19A2-Thiamine inward structure
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8z7z
Q-score: 0.389
SLC19A2-Pyridoxine inward structure
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8z80
Q-score: 0.288
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
- Thiamine transporter 1 (55 kDa, Protein from Homo sapiens)
- Slc19a3-thiamine complex (Complex from Homo sapiens)
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8z8z
Q-score: 0.589
Xiong Q, Zhu Z, Li T, Li X, Zhou Z, Chao Y, Yang C, Feng S, Qu Q, Li D
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01474-5 Pubmed: 39824977 ]
- Lychos (127 kDa, Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Water (18 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (4~{z},7~{z},10~{z},13~{z},16~{z},19~{z})-docosa-4,7,10,13,16,19-hexaenoate (764 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lysosomal cholesterol signaling protein,fluorescent protein (127 kDa, Protein from synthetic construct)
Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A.
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8xql
Q-score: 0.469
Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ
Nature (2024) 631 pp. 459-466 [ DOI: doi:10.1038/s41586-024-07569-9 Pubmed: 38776963 ]
- Exo-alpha-sialidase,taste receptor type 2 member 14,lgbit (110 kDa, Protein from synthetic construct)
- Nanobody 35 (14 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Complex of tas2r14-minigsg with aristolochic acid a (Complex from Homo sapiens)
- 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid (341 Da, Ligand)
Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A.
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8xqn
Q-score: 0.442
Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ
Nature (2024) 631 pp. 459-466 [ DOI: doi:10.1038/s41586-024-07569-9 Pubmed: 38776963 ]
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Exo-alpha-sialidase,taste receptor type 2 member 14,lgbit (110 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Structure of human class t gpcr tas2r14-dngi complex with aristolochic acid a. (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid (341 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (42 kDa, Protein from Homo sapiens)
Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A.
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8xqo
Q-score: 0.48
Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ
Nature (2024) 631 pp. 459-466 [ DOI: doi:10.1038/s41586-024-07569-9 Pubmed: 38776963 ]
- Structure of human class t gpcr tas2r14-gi complex with aristolochic acid a. (Complex from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Exo-alpha-sialidase,taste receptor type 2 member 14,lgbit (110 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (42 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid (341 Da, Ligand)
Structure of human class T GPCR TAS2R14-Gustducin complex with Aristolochic acid A.
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xqp
Q-score: 0.359
Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ
Nature (2024) 631 pp. 459-466 [ DOI: doi:10.1038/s41586-024-07569-9 Pubmed: 38776963 ]
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (42 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Exo-alpha-sialidase,taste receptor type 2 member 14,lgbit (110 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Structure of human class t gpcr tas2r14-gustducin complex with aristolochic acid a. (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid (341 Da, Ligand)
Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid.
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xqr
Q-score: 0.386
Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ
Nature (2024) 631 pp. 459-466 [ DOI: doi:10.1038/s41586-024-07569-9 Pubmed: 38776963 ]
- Exo-alpha-sialidase,taste receptor type 2 member 14,lgbit (110 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (14 kDa, Protein from Homo sapiens)
- Structure 2 of human class t gpcr tas2r14-minigs/gust complex with flufenamic acid. (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 2-[[3-(trifluoromethyl)phenyl]amino] benzoic acid (281 Da, Ligand)