The BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8hii
Q-score: 0.338
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- The bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8hij
Q-score: 0.296
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- The 5-mthf-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- N-[4-({[(6s)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid (459 Da, Ligand)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8hik
Q-score: 0.249
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Thiamine diphosphate (425 Da, Ligand)
- The tpp-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
Human L-TGF-beta1 in complex with the anchor protein LRRC33
Resolution: 4.01 Å
EM Method: Single-particle
Fitted PDBs: 7y1r
Q-score: 0.187
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ DOI: doi:10.1038/s41467-022-32655-9 Pubmed: 36008481 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- L-tgf-beta1 in complex with its anchor protein lrrc33 (150 kDa, Complex from Homo sapiens)
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- Transforming growth factor beta activator lrrc33 (72 kDa, Protein from Homo sapiens)
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7y1t
Q-score: 0.428
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ DOI: doi:10.1038/s41467-022-32655-9 Pubmed: 36008481 ]
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- Complex of integrin alphav/beta8 and l-tgf-beta1 at a ratio of 1:2 (210 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Integrin alpha-v (69 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Integrin beta-8 (53 kDa, Protein from Homo sapiens)
Complex of integrin alphaV/beta8, L-TGF-beta1, and LRRC33 at a ratio of 2:2:1
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ DOI: doi:10.1038/s41467-022-32655-9 Pubmed: 36008481 ]
- Integrin alphav (Protein from Homo sapiens)
- L-tgf-beta1 (Protein from Homo sapiens)
- Lrrc33 (Protein from Homo sapiens)
- Complex of integrin alphav/beta8, l-tgf-beta1, and lrrc33 at a ratio of 2:2:1 (400 kDa, Complex from Homo sapiens)
- Integrin beta8 (Protein from Homo sapiens)
Full-length Sarm1 in a self-inhibited state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7cm5
Q-score: 0.477
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z
Nature (2020) 588 pp. 658-663 [ Pubmed: 33053563 DOI: doi:10.1038/s41586-020-2862-z ]
- Octamer of full-length sarm1 (640 MDa, Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (80 kDa, Protein from Homo sapiens)
NAD+-bound Sarm1 in the self-inhibited state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7cm6
Q-score: 0.453
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z
Nature (2020) 588 pp. 658-663 [ Pubmed: 33053563 DOI: doi:10.1038/s41586-020-2862-z ]
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Octamer of full-length sarm1 (640 MDa, Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (80 kDa, Protein from Homo sapiens)
NAD+-bound Sarm1 E642A in the self-inhibited state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7cm7
Q-score: 0.476
Jiang Y, Liu T, Lee CH, Chang Q, Yang J, Zhang Z
Nature (2020) 588 pp. 658-663 [ Pubmed: 33053563 DOI: doi:10.1038/s41586-020-2862-z ]
- Nad(+) hydrolase sarm1 (80 kDa, Protein from Homo sapiens)
- Octamer of full-length sarm1 e642a (640 MDa, Complex from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)