Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8xr8
Q-score: 0.535
Sun J, Zheng T, Jia M, Wang Y, Yang J, Liu Y, Yang P, Xie Y, Sun H, Tong Q, Li J, Yang J, Fu G, Shi Y, Qi J, Liu W, Liu J, Tian WX, Gao GF, Bi Y
Nat Commun (2024) 15 pp. 10012-10012 [ DOI: doi:10.1038/s41467-024-54374-z Pubmed: 39562538 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The structure of influenza h2 avian fj hemagglutinin with avian receptor (Complex from Influenza A virus)
- Hemagglutinin (56 kDa, Protein from Influenza A virus)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 8xra
Q-score: 0.422
Sun J, Zheng T, Jia M, Wang Y, Yang J, Liu Y, Yang P, Xie Y, Sun H, Tong Q, Li J, Yang J, Fu G, Shi Y, Qi J, Liu W, Liu J, Tian WX, Gao GF, Bi Y
Nat Commun (2024) 15 pp. 10012-10012 [ DOI: doi:10.1038/s41467-024-54374-z Pubmed: 39562538 ]
- Hemagglutinin (56 kDa, Protein from Influenza A virus)
- The structure of influenza h2 human singapore hemagglutinin with avian receptor (Complex from Influenza A virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xrc
Q-score: 0.542
Sun J, Zheng T, Jia M, Wang Y, Yang J, Liu Y, Yang P, Xie Y, Sun H, Tong Q, Li J, Yang J, Fu G, Shi Y, Qi J, Liu W, Liu J, Tian WX, Gao GF, Bi Y
Nat Commun (2024) 15 pp. 10012-10012 [ DOI: doi:10.1038/s41467-024-54374-z Pubmed: 39562538 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The structure of influenza h2 avian fj s144n hemagglutinin with avian receptor (Complex from Influenza A virus)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
- Hemagglutinin (56 kDa, Protein from Influenza A virus)
Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 avian influenza virus
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8xrd
Q-score: 0.484
Sun J, Zheng T, Jia M, Wang Y, Yang J, Liu Y, Yang P, Xie Y, Sun H, Tong Q, Li J, Yang J, Fu G, Shi Y, Qi J, Liu W, Liu J, Tian WX, Gao GF, Bi Y
Nat Commun (2024) 15 pp. 10012-10012 [ DOI: doi:10.1038/s41467-024-54374-z Pubmed: 39562538 ]
- Hemagglutinin (56 kDa, Protein from Influenza A virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The structure of influenza h2 avian fj hemagglutinin with human receptor (Complex from Influenza A virus)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
Fentanyl-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ef5
Q-score: 0.39
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- N-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (336 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Morphine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ef6
Q-score: 0.471
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (7r,7as,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1h-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol (285 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
Oliceridine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8efb
Q-score: 0.462
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- N-[(3-methoxythiophen-2-yl)methyl]-2-[(9r)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
SR17018-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8efl
Q-score: 0.463
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2h-benzimidazol-2-one (410 Da, Ligand)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
PZM21-bound mu-opioid receptor-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8efo
Q-score: 0.472
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- N-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-n'-[(2s)-1-(thiophen-3-yl)propan-2-yl]urea (361 Da, Ligand)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
DAMGO-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8efq
Q-score: 0.42
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Damgo (470 Da, Protein from synthetic construct)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ethanolamine (61 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)