CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k4s
Q-score: 0.521
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Complex of mrgprx4 with gq and agonist dca-3p (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8kex
Q-score: 0.416
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- Cryo-em structure of mrgprx4 complex with agonist dca-3p (Complex from Homo sapiens)
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
Hofler A, Yu J, Yang J, Zhang Z, Chang L, McLaughlin SH, Grime GW, Garman EF, Boland A, Barford D
Nat Commun (2024) 15 pp. 10074-10074 [ DOI: doi:10.1038/s41467-024-54398-5 Pubmed: 39567505 ]
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex (apc/c) bound to co-activator cdh1 (1 MDa, Complex from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- F-box only protein 5 (50 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
Human TOM complex with whole Tom20
Resolution: 5.92 Å
EM Method: Single-particle
Fitted PDBs: 8xva
Q-score: 0.225
Su J, Tian X, Wang Z, Yang J, Sun S, Sui SF
Pnas Nexus (2024) 3 pp. pgae269-pgae269 [ DOI: doi:10.1093/pnasnexus/pgae269 Pubmed: 39071881 ]
- Mitochondrial import receptor subunit tom5 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom6 homolog (8 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom40 homolog (37 kDa, Protein from Homo sapiens)
- Tom complex with whole tom20 (168 MDa, Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom22 homolog (15 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom20 homolog (16 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom7 homolog (6 kDa, Protein from Homo sapiens)
Su J, Tian X, Wang Z, Yang J, Sun S, Sui SF
Pnas Nexus (2024) 3 pp. pgae269-pgae269 [ DOI: doi:10.1093/pnasnexus/pgae269 Pubmed: 39071881 ]
- Tom complex with whole tom20 (168 MDa, Complex from Homo sapiens)
Su J, Tian X, Wang Z, Yang J, Sun S, Sui SF
Pnas Nexus (2024) 3 pp. pgae269-pgae269 [ DOI: doi:10.1093/pnasnexus/pgae269 Pubmed: 39071881 ]
- Tom complex with whole tom20 (168 MDa, Complex from Homo sapiens)
Focused refined map of the Anaphase-promoting complex/cyclosome (APC/C) with mask 3
Cryo-EM structure of human TMEM87A A308M
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8kb4
Q-score: 0.507
Kang H, Han AR, Zhang A, Jeong H, Koh W, Lee JM, Lee H, Jo HY, Maria-Solano MA, Bhalla M, Kwon J, Roh WS, Yang J, An HJ, Choi S, Kim HM, Lee CJ
Nat Commun (2024) 15 pp. 5830-5830 [ DOI: doi:10.1038/s41467-024-49297-8 Pubmed: 38992057 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (9r,12r)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate (481 Da, Ligand)
- Transmembrane protein 87a a308m with gfp tag and twin-strep tag (Cellular component from Homo sapiens)
- Transmembrane protein 87a,egfp (96 kDa, Protein from Human adenovirus C serotype 2)
Structure of the human outer kinetochore KMN network complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ppr
Q-score: 0.341
Yatskevich S, Yang J, Bellini D, Zhang Z, Barford D
Nat Struct Mol Biol (2024) 31 pp. 874-883 [ Pubmed: 38459127 DOI: doi:10.1038/s41594-024-01249-y ]
- Kinetochore protein spc25 (26 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Polyamine-modulated factor 1 (23 kDa, Protein from Homo sapiens)
- Outer kinetochore kmn network junction complex (Complex from Homo sapiens)
- Kinetochore-associated protein dsn1 homolog (40 kDa, Protein from Homo sapiens)
- Kinetochore scaffold 1 (265 kDa, Protein from Homo sapiens)
- Zw10 interactor (31 kDa, Protein from Homo sapiens)
- Kinetochore-associated protein nsl1 homolog (32 kDa, Protein from Homo sapiens)
- Kinetochore protein spc24 (22 kDa, Protein from Homo sapiens)
- Protein mis12 homolog (24 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8s4g, 9gaw
Q-score: 0.37
Hofler A, Yu J, Yang J, Zhang Z, Chang L, McLaughlin SH, Grime GW, Garman EF, Boland A, Barford D
Nat Commun (2024) 15 pp. 10074-10074 [ Pubmed: 39567505 DOI: doi:10.1038/s41467-024-54398-5 ]
- Anaphase-promoting complex subunit 4 (93 kDa, Protein from Homo sapiens)
- Cell division cycle protein 27 homolog (91 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 7 (66 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 1 (216 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit cdc26 (9 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 16 (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Anaphase-promoting complex subunit 2 (93 kDa, Protein from Homo sapiens)
- Fizzy-related protein homolog (55 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 11 (9 kDa, Protein from Homo sapiens)
- Cell division cycle protein 16 homolog (71 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 15 (14 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 5 (85 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex (apc/c) bound to co-activator cdh1 (1 MDa, Complex from Homo sapiens)
- F-box only protein 5 (50 kDa, Protein from Homo sapiens)
- Anaphase-promoting complex subunit 13 (8 kDa, Protein from Homo sapiens)
- Cell division cycle protein 23 homolog (68 kDa, Protein from Homo sapiens)