Structure of TAX-4_R421W w/cGMP open state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7n15
Q-score: 0.571
Zheng X, Li H, Hu Z, Su D, Yang J
Commun Biol (2022) 5 pp. 190-190 [ DOI: doi:10.1038/s42003-022-03120-6 Pubmed: 35233102 ]
- Cyclic nucleotide-gated cation channel (84 kDa, Protein from Caenorhabditis elegans)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated channel tax-4 with an achromatopsia-associated missense mutation r421w (Complex from Caenorhabditis elegans)
Structure of TAX-4_R421W apo closed state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7n16
Q-score: 0.49
Structure of TAX-4_R421W apo open state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7n17
Q-score: 0.514
Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7rhs
Q-score: 0.538
Nat Struct Mol Biol (2022) 29 pp. 40-46 [ DOI: doi:10.1038/s41594-021-00699-y Pubmed: 34969976 ]
- Cyclic nucleotide-gated cation channel beta-3 (95 kDa, Protein from Homo sapiens)
- Cyclic nucleotide-gated cation channel alpha-3 (80 kDa, Protein from Homo sapiens)
- Native human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6wej
Q-score: 0.582
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Structure of cgmp-unbound wt tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Sodium ion (22 Da, Ligand)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6wek
Q-score: 0.593
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Structure of cgmp-bound wt tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6wel
Q-score: 0.616
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Structure of cgmp-unbound f403v/v407a mutant tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- Sodium ion (22 Da, Ligand)