Structure of TAX-4_R421W w/cGMP open state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7n15
Q-score: 0.571
Zheng X, Li H, Hu Z, Su D, Yang J
Commun Biol (2022) 5 pp. 190-190 [ DOI: doi:10.1038/s42003-022-03120-6 Pubmed: 35233102 ]
- Cyclic nucleotide-gated cation channel (84 kDa, Protein from Caenorhabditis elegans)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated channel tax-4 with an achromatopsia-associated missense mutation r421w (Complex from Caenorhabditis elegans)
Structure of TAX-4_R421W apo closed state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7n16
Q-score: 0.49
Structure of TAX-4_R421W apo open state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7n17
Q-score: 0.514
Structure of cGMP-unbound WT TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6wej
Q-score: 0.582
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Structure of cgmp-unbound wt tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Sodium ion (22 Da, Ligand)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6wek
Q-score: 0.593
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Structure of cgmp-bound wt tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6wel
Q-score: 0.616
Zheng X, Fu Z, Su D, Zhang Y, Li M, Pan Y, Li H, Li S, Grassucci RA, Ren Z, Hu Z, Li X, Zhou M, Li G, Frank J, Yang J
Nat Struct Mol Biol (2020) 27 pp. 625-634 [ DOI: doi:10.1038/s41594-020-0433-5 Pubmed: 32483338 ]
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Structure of cgmp-unbound f403v/v407a mutant tax-4 reconstituted in lipid nanodiscs (Complex from Caenorhabditis elegans)
- Cyclic nucleotide-gated cation channel (83 kDa, Protein from Caenorhabditis elegans)
- Sodium ion (22 Da, Ligand)
Human apo-TRPML3 channel at pH 7.4
Resolution: 4.06 Å
EM Method: Single-particle
Fitted PDBs: 6aye
Q-score: 0.401
Zhou X, Li M, Su D, Jia Q, Li H, Li X, Yang J
Nat Struct Mol Biol (2017) 24 pp. 1146-1154 [ Pubmed: 29106414 DOI: doi:10.1038/nsmb.3502 ]
- Human trpml3 apo channel at ph 7.4 (Complex from Homo sapiens)
- Mucolipin-3 (64 kDa, Protein from Homo sapiens)
TRPML3/ML-SA1 complex at pH 7.4
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 6ayf
Q-score: 0.44
Zhou X, Li M, Su D, Jia Q, Li H, Li X, Yang J
Nat Struct Mol Biol (2017) 24 pp. 1146-1154 [ Pubmed: 29106414 DOI: doi:10.1038/nsmb.3502 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mucolipin-3 (64 kDa, Protein from Homo sapiens)
- Trpml3 channel bound with a agonist ml-sa1 (Complex from Homo sapiens)
Human Apo-TRPML3 channel at pH 4.8
Resolution: 4.65 Å
EM Method: Single-particle
Fitted PDBs: 6ayg
Q-score: 0.336
Zhou X, Li M, Su D, Jia Q, Li H, Li X, Yang J
Nat Struct Mol Biol (2017) 24 pp. 1146-1154 [ Pubmed: 29106414 DOI: doi:10.1038/nsmb.3502 ]
- Mucolipin-3 (64 kDa, Protein from Homo sapiens)
- Human trpml3 channel at ph 4.8 (Complex from Homo sapiens)
Structure of a eukaryotic cyclic nucleotide-gated channel
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 5h3o
Q-score: 0.456
Li M, Zhou X, Wang S, Michailidis I, Gong Y, Su D, Li H, Li X, Yang J
Nature (2017) 542 pp. 60-65 [ Pubmed: 28099415 DOI: doi:10.1038/nature20819 ]
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated cation channel (84 kDa, Protein from Caenorhabditis elegans)
- Cyclic nucleotide-gated (cng) channels (Complex from Caenorhabditis elegans)
- Sodium ion (22 Da, Ligand)