CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k4s
Q-score: 0.521
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Complex of mrgprx4 with gq and agonist dca-3p (Complex from Homo sapiens)
CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8kex
Q-score: 0.416
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- Cryo-em structure of mrgprx4 complex with agonist dca-3p (Complex from Homo sapiens)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state I
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8yhd
Q-score: 0.5
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- A protein (27 kDa, Protein from metagenome)
- A protein (70 kDa, Protein from metagenome)
- Rna (35-mer) (16 kDa, RNA from metagenome)
- A protein (22 kDa, Protein from metagenome)
- Zinc ion (65 Da, Ligand)
- A protein (Complex from metagenome)
- Rna (53-mer) (21 kDa, RNA from metagenome)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8yhe
Q-score: 0.506
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Protein structure (Complex from metagenome)
- Protein structure (70 kDa, Protein from metagenome)
- Protein structure (22 kDa, Protein from metagenome)
- Rna (29-mer) (16 kDa, RNA from metagenome)
- Rna (46-mer) (15 kDa, RNA from metagenome)
- Zinc ion (65 Da, Ligand)
- Protein structure (27 kDa, Protein from metagenome)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8z4j
Q-score: 0.507
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Protein structure (22 kDa, Protein from metagenome)
- Rna (38-mer) (19 kDa, RNA from metagenome)
- Rna (34-mer) (19 kDa, RNA from metagenome)
- Protein structure (27 kDa, Protein from metagenome)
- A protein (Complex from metagenome)
- Zinc ion (65 Da, Ligand)
- Protein structure (70 kDa, Protein from metagenome)
Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8z4l
Q-score: 0.531
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Rna (49-mer) (19 kDa, RNA from metagenome)
- Rna (40-mer) (19 kDa, RNA from metagenome)
- A protein (27 kDa, Protein from metagenome)
- A protein (70 kDa, Protein from metagenome)
- A protein (22 kDa, Protein from metagenome)
- Zinc ion (65 Da, Ligand)
- A protein (Complex from metagenome)
Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state +I
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8z99
Q-score: 0.487
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- A protein (27 kDa, Protein from metagenome)
- Rna (54-mer) (19 kDa, RNA from metagenome)
- Rna (49-mer) (19 kDa, RNA from metagenome)
- A protein (70 kDa, Protein from metagenome)
- A protein (22 kDa, Protein from metagenome)
- Zinc ion (65 Da, Ligand)
- A protein (Complex from metagenome)
Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state I
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8z9c
Q-score: 0.528
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Protein structure (22 kDa, Protein from metagenome)
- Protein structure (Complex from metagenome)
- Rna (48-mer) (19 kDa, RNA from metagenome)
- Protein structure (27 kDa, Protein from metagenome)
- Rna (41-mer) (17 kDa, RNA from metagenome)
- Zinc ion (65 Da, Ligand)
- Protein structure (70 kDa, Protein from metagenome)
Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state II
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8z9e
Q-score: 0.496
Yang J, Li X, He Q, Wang X, Tang J, Wang T, Zhang Y, Yu F, Zhang S, Liu Z, Zhang L, Liao F, Yin H, Zhao H, Deng Z, Zhang H
Nature (2024) 633 pp. 465-472 [ Pubmed: 39143216 DOI: doi:10.1038/s41586-024-07815-0 ]
- Protein structure (22 kDa, Protein from metagenome)
- Protein structure (Complex from metagenome)
- Rna (34-mer) (19 kDa, RNA from metagenome)
- Protein structure (27 kDa, Protein from metagenome)
- Zinc ion (65 Da, Ligand)
- Rna (39-mer) (19 kDa, RNA from metagenome)
- Protein structure (70 kDa, Protein from metagenome)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k98
Q-score: 0.486
Yin H, Li X, Wang X, Zhang C, Gao J, Yu G, He Q, Yang J, Liu X, Wei Y, Li Z, Zhang H
Nat Commun (2024) 15 pp. 2692-2692 [ Pubmed: 38538592 DOI: doi:10.1038/s41467-024-47030-z ]
- A protein (29 kDa, Protein from Bacillus halotolerans)
- Cryo-em structure of a protein (Complex from Bacillus halotolerans)
- A protein (118 kDa, Protein from Bacillus halotolerans)