The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8ijq
Q-score: 0.461
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8ijr
Q-score: 0.485
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024) 31 pp. 884-895 [ DOI: doi:10.1038/s41594-024-01237-2 Pubmed: 38388831 ]
- Phosphoric acid mono-(2-amino-ethyl) ester (141 Da, Ligand)
- Sphingomyelin synthase-related protein 1 (48 kDa, Protein from Homo sapiens)
- The cryo-em structure of human sphingomyelin synthase-related protein in complex with diacylglycerol/phosphoethanolamine (Complex from Homo sapiens)
- (2s)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl (11z)-octadec-11-enoate (594 Da, Ligand)
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8w9w
Q-score: 0.377
Hu K, Zhang Q, Chen Y, Yang J, Xia Y, Rao B, Li S, Shen Y, Cao M, Lu H, Qin A, Jiang XC, Yao D, Zhao J, Zhou L, Cao Y
Nat Struct Mol Biol (2024) 31 pp. 884-895 [ DOI: doi:10.1038/s41594-024-01237-2 Pubmed: 38388831 ]
- Phosphoric acid mono-(2-amino-ethyl) ester (141 Da, Ligand)
- Sphingomyelin synthase-related protein 1 (31 kDa, Protein from Homo sapiens)
- The cryo-em structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine (Complex from Homo sapiens)
- ~{n}-[(~{z},2~{s},3~{r})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide (467 Da, Ligand)
Fentanyl-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ef5
Q-score: 0.39
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ Pubmed: 36368306 DOI: doi:10.1016/j.cell.2022.09.041 ]
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- N-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (336 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Morphine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ef6
Q-score: 0.471
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ Pubmed: 36368306 DOI: doi:10.1016/j.cell.2022.09.041 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (7r,7as,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1h-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol (285 Da, Ligand)
SR17018-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8efl
Q-score: 0.463
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ Pubmed: 36368306 DOI: doi:10.1016/j.cell.2022.09.041 ]
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2h-benzimidazol-2-one (410 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
PZM21-bound mu-opioid receptor-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8efo
Q-score: 0.472
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ Pubmed: 36368306 DOI: doi:10.1016/j.cell.2022.09.041 ]
- N-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-n'-[(2s)-1-(thiophen-3-yl)propan-2-yl]urea (361 Da, Ligand)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
DAMGO-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8efq
Q-score: 0.42
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ Pubmed: 36368306 DOI: doi:10.1016/j.cell.2022.09.041 ]
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Ethanolamine (61 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Damgo (470 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Human L-TGF-beta1 in complex with the anchor protein LRRC33
Resolution: 4.01 Å
EM Method: Single-particle
Fitted PDBs: 7y1r
Q-score: 0.187
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ Pubmed: 36008481 DOI: doi:10.1038/s41467-022-32655-9 ]
- Transforming growth factor beta activator lrrc33 (72 kDa, Protein from Homo sapiens)
- L-tgf-beta1 in complex with its anchor protein lrrc33 (150 kDa, Complex from Homo sapiens)
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7y1t
Q-score: 0.428
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ Pubmed: 36008481 DOI: doi:10.1038/s41467-022-32655-9 ]
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Integrin alpha-v (69 kDa, Protein from Homo sapiens)
- Complex of integrin alphav/beta8 and l-tgf-beta1 at a ratio of 1:2 (210 kDa, Complex from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Integrin beta-8 (53 kDa, Protein from Homo sapiens)