Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 2
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8euc
Q-score: 0.42
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (78 kDa, Protein from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (92 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in gdn (Complex from Homo sapiens)
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, closed state
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8ev8
Q-score: 0.542
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- Truncated human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in lipid nanodisc (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (84 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (63 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8ev9
Q-score: 0.482
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- Truncated human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in lipid nanodisc (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (84 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (63 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8eva
Q-score: 0.473
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- Truncated human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in lipid nanodisc (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (84 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (63 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8evb
Q-score: 0.414
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- Truncated human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in lipid nanodisc (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (84 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (63 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, open state
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8evc
Q-score: 0.48
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- Truncated human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in lipid nanodisc (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (84 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (63 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8etp
Q-score: 0.459
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel alpha-3 (78 kDa, Protein from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (92 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 1
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8eu3
Q-score: 0.432
Nat Commun (2023) 14 pp. 4284-4284 [ DOI: doi:10.1038/s41467-023-39971-8 Pubmed: 37463923 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cyclic nucleotide-gated cation channel alpha-3 (78 kDa, Protein from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-3 (92 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Human cone photoreceptor heterotetrameric cng channel cnga3/cngb3 in complex with cgmp in gdn (Complex from Homo sapiens)
Structure of TAX-4_R421W w/cGMP open state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7n15
Q-score: 0.571
Zheng X, Li H, Hu Z, Su D, Yang J
Commun Biol (2022) 5 pp. 190-190 [ DOI: doi:10.1038/s42003-022-03120-6 Pubmed: 35233102 ]
- Cyclic nucleotide-gated cation channel (84 kDa, Protein from Caenorhabditis elegans)
- 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine (758 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated channel tax-4 with an achromatopsia-associated missense mutation r421w (Complex from Caenorhabditis elegans)
Structure of TAX-4_R421W apo closed state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7n16
Q-score: 0.49