Cryo-EM structure of S. cerevisiae PolE-core-DNA
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9b8r
Q-score: 0.332
Yuan Z, Georgescu R, Yao NY, Yurieva O, O'Donnell ME, Li H
Science (2024) 385 pp. eadk5901-eadk5901 [ Pubmed: 39088616 DOI: doi:10.1126/science.adk5901 ]
- Pole-core-dna complex (Complex from Saccharomyces cerevisiae)
- Primer dna (3 kDa, DNA from DNA molecule)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna polymerase epsilon catalytic subunit (133 kDa, Protein from Saccharomyces cerevisiae)
- Template dna (3 kDa, DNA from DNA molecule)
Human polymerase epsilon bound to PCNA and DNA in the nucleotide exchange state
Resolution: 5.01 Å
EM Method: Single-particle
Fitted PDBs: 9b8s
Q-score: 0.212
He Q, Wang F, Yao NY, O'Donnell ME, Li H
Nat Commun (2024) 15 pp. 7847-7847 [ DOI: doi:10.1038/s41467-024-52257-x Pubmed: 39245668 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Dna polymerase epsilon catalytic subunit a (261 kDa, Protein from Homo sapiens)
- The dna bound pol epsilon and pcna complex (450 kDa, Complex from Homo sapiens)
- Dna (5'-d(p*gp*tp*gp*ap*tp*gp*cp*tp*tp*tp*ap*gp*ap*tp*tp*tp*tp*tp*c)-3') (10 kDa, DNA from DNA molecule)
- Dna (5'-d(p*ap*ap*ap*gp*tp*gp*ap*ap*ap*ap*ap*tp*cp*tp*ap*ap*ap*gp*cp*ap*tp*cp*ap*c)-3') (18 kDa, DNA from DNA molecule)
Human polymerase epsilon bound to PCNA and DNA in the nucleotide bound state
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 9b8t
Q-score: 0.39
He Q, Wang F, Yao NY, O'Donnell ME, Li H
Nat Commun (2024) 15 pp. 7847-7847 [ DOI: doi:10.1038/s41467-024-52257-x Pubmed: 39245668 ]
- Iron/sulfur cluster (351 Da, Ligand)
- Primer dna (10 kDa, DNA from DNA molecule)
- Dna polymerase epsilon catalytic subunit (261 kDa, Protein from Homo sapiens)
- Template dna (18 kDa, DNA from DNA molecule)
- Magnesium ion (24 Da, Ligand)
- The dna bound pol epsilon and pcna complex (450 kDa, Complex from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Thymidine-5'-triphosphate (482 Da, Ligand)
Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA complex in Apo state conformation I
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8tw7
Q-score: 0.488
Yuan Z, Georgescu R, Yao NY, Yurieva O, O'Donnell ME, Li H
Science (2024) 385 pp. eadk5901-eadk5901 [ Pubmed: 39088616 DOI: doi:10.1126/science.adk5901 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Saccharomyces cerevisiae)
- Chromosome transmission fidelity protein 18 (30 kDa, Protein from Saccharomyces cerevisiae)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Replication factor c subunit 3 (36 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 4 (35 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ctf18-rfc-pcna complex (Complex from Saccharomyces cerevisiae)
- Replication factor c subunit 5 (39 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 2 (38 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA complex in Apo state conformation I
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tw8
Q-score: 0.426
Yuan Z, Georgescu R, Yao NY, Yurieva O, O'Donnell ME, Li H
Science (2024) 385 pp. eadk5901-eadk5901 [ Pubmed: 39088616 DOI: doi:10.1126/science.adk5901 ]
- Proliferating cell nuclear antigen (28 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 4 (35 kDa, Protein from Saccharomyces cerevisiae)
- Chromosome transmission fidelity protein 18 (30 kDa, Protein from Saccharomyces cerevisiae)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Replication factor c subunit 3 (36 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ctf18-rfc-pcna complex (Complex from Saccharomyces cerevisiae)
- Replication factor c subunit 5 (39 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 2 (38 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of S. cerevisiae PolE-Ctf18-8-1-DNA
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8tw9
Q-score: 0.438
Yuan Z, Georgescu R, Yao NY, Yurieva O, O'Donnell ME, Li H
Science (2024) 385 pp. eadk5901-eadk5901 [ Pubmed: 39088616 DOI: doi:10.1126/science.adk5901 ]
- Dna polymerase epsilon catalytic subunit a (255 kDa, Protein from Saccharomyces cerevisiae)
- Template dna (4 kDa, DNA from synthetic construct)
- Chromosome transmission fidelity protein 8 (15 kDa, Protein from Saccharomyces cerevisiae)
- Iron/sulfur cluster (351 Da, Ligand)
- Primer dna (2 kDa, DNA from synthetic construct)
- Sister chromatid cohesion protein dcc1 (44 kDa, Protein from Saccharomyces cerevisiae)
- Ctf18-rfc-pcna complex (Complex from Saccharomyces cerevisiae)
- Chromosome transmission fidelity protein 18 (3 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8twa
Q-score: 0.349
Yuan Z, Georgescu R, Yao NY, Yurieva O, O'Donnell ME, Li H
Science (2024) 385 pp. eadk5901-eadk5901 [ Pubmed: 39088616 DOI: doi:10.1126/science.adk5901 ]
- Chromosome transmission fidelity protein 18 (84 kDa, Protein from Saccharomyces cerevisiae)
- Dna polymerase epsilon catalytic subunit a (255 kDa, Protein from Saccharomyces cerevisiae)
- Proliferating cell nuclear antigen (28 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 4 (35 kDa, Protein from Saccharomyces cerevisiae)
- Template dna (4 kDa, DNA from synthetic construct)
- Ctf18-rfc-pcna-pole-dna complex (Complex from Saccharomyces cerevisiae)
- Chromosome transmission fidelity protein 8 (15 kDa, Protein from Saccharomyces cerevisiae)
- Iron/sulfur cluster (351 Da, Ligand)
- Replication factor c subunit 5 (39 kDa, Protein from Saccharomyces cerevisiae)
- Primer dna (2 kDa, DNA from synthetic construct)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 3 (36 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Sister chromatid cohesion protein dcc1 (44 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromosome transmission fidelity protein 18 (3 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 2 (38 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-DNA complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8twb
Q-score: 0.482
Yuan Z, Georgescu R, Yao NY, Yurieva O, O'Donnell ME, Li H
Science (2024) 385 pp. eadk5901-eadk5901 [ Pubmed: 39088616 DOI: doi:10.1126/science.adk5901 ]
- Template dna (5 kDa, DNA from synthetic construct)
- Proliferating cell nuclear antigen (28 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 4 (35 kDa, Protein from Saccharomyces cerevisiae)
- Chromosome transmission fidelity protein 18 (30 kDa, Protein from Saccharomyces cerevisiae)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Replication factor c subunit 3 (36 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ctf18-rfc-pcna complex (Complex from Saccharomyces cerevisiae)
- Primer dna (5 kDa, DNA from synthetic construct)
- Replication factor c subunit 5 (39 kDa, Protein from Saccharomyces cerevisiae)
- Replication factor c subunit 2 (38 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM map of human clmap-clamp loader ATAD5-RFC-gapped PCNA complex in intermediate state 3
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8ui7
Q-score: 0.229
Wang F, He Q, Yao NY, O'Donnell ME, Li H
Nat Struct Mol Biol (2024) 31 pp. 1680-1691 [ Pubmed: 38871854 DOI: doi:10.1038/s41594-024-01332-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Atad5-rfc-gapped pcna (320 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Atpase family aaa domain-containing protein 5 (116 kDa, Protein from Homo sapiens)
Cryo-EM map of human clamp-clamp loader ATAD5-RFC-two PCNAs complex in intermediate state 3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ui8
Q-score: 0.464
Wang F, He Q, Yao NY, O'Donnell ME, Li H
Nat Struct Mol Biol (2024) 31 pp. 1680-1691 [ Pubmed: 38871854 DOI: doi:10.1038/s41594-024-01332-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Atad5-rfc-closed pcna (320 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
- Atpase family aaa domain-containing protein 5 (116 kDa, Protein from Homo sapiens)