Cryo-EM structure of the anamorelin-bound ghrelin receptor and Gq complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jsr
Q-score: 0.566
Shiimura Y, Im D, Tany R, Asada H, Kise R, Kurumiya E, Wakasugi-Masuho H, Yasuda S, Matsui K, Kishikawa JI, Kato T, Murata T, Kojima M, Iwata S, Masuho I
Nat Struct Mol Biol (2025) [ Pubmed: 39833471 DOI: doi:10.1038/s41594-024-01481-6 ]
- Anamorelin-bound ghrelin receptor in complex with gq (190 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Engineered g-alpha-q (41 kDa, Protein from Homo sapiens)
- 2-azanyl-n-[(2r)-1-[(3r)-3-[dimethylamino(methyl)carbamoyl]-3-(phenylmethyl)piperidin-1-yl]-3-(1h-indol-3-yl)-1-oxidanylidene-propan-2-yl]-2-methyl-propanamide (546 Da, Ligand)
- Growth hormone secretagogue receptor type 1 (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (14 kDa, Protein from Lama glama)
- Scfv16 (27 kDa, Protein from Mus musculus)
Cryo-EM structure of the inhibitor-bound Vo complex from Enterococcus hirae
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8wci
Q-score: 0.725
Suzuki K, Goto Y, Otomo A, Shimizu K, Abe S, Moriyama K, Yasuda S, Hashimoto Y, Kurushima J, Mikuriya S, Imai FL, Adachi N, Kawasaki M, Sato Y, Ogasawara S, Iwata I, Senda T, Ikeguchi M, Tomita H, Iino R, Moriya T, Murata T
To Be Published
- V-atpase (735 kDa, Complex from Enterococcus hirae ATCC 9790)
- Sodium ion (22 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- V-type sodium atpase subunit i (76 kDa, Protein from Enterococcus hirae ATCC 9790)
- V-type sodium atpase subunit k (16 kDa, Protein from Enterococcus hirae ATCC 9790)
- Water (18 Da, Ligand)
- N,n-dimethyl-4-(5-methyl-1h-benzimidazol-2-yl)aniline (251 Da, Ligand)
Cryo-EM Structure of inhibitor-free hERG Channel
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8zyn
Q-score: 0.469
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
- Potassium voltage-gated channel subfamily h member 2 (91 kDa, Protein from Homo sapiens)
- Potassium channel (Complex from Homo sapiens)
Cryo-EM Structure of astemizole-bound hERG Channel
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8zyo
Q-score: 0.479
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
Cryo-EM Structure of E-4031-bound hERG Channel
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8zyp
Q-score: 0.503
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
Cryo-EM Structure of pimozide-bound hERG Channel
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8zyq
Q-score: 0.488
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8y6h
Q-score: 0.608
Hamaguchi-Suzuki N, Adachi N, Moriya T, Yasuda S, Kawasaki M, Suzuki K, Ogasawara S, Anzai N, Senda T, Murata T
Biochem Biophys Res Commun (2024) 709 pp. 149855-149855 [ DOI: doi:10.1016/j.bbrc.2024.149855 Pubmed: 38579618 ]
- Atp-dependent translocase abcb1,mneongreen (170 kDa, Protein from Homo sapiens)
- Uic2 fab light chain (24 kDa, Protein from Mus musculus)
- Elacridar (563 Da, Ligand)
- Multidrug resistance protein (Complex from Homo sapiens)
- Uic2 fab heavy chain (24 kDa, Protein from Mus musculus)
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8y6i
Q-score: 0.576
Hamaguchi-Suzuki N, Adachi N, Moriya T, Yasuda S, Kawasaki M, Suzuki K, Ogasawara S, Anzai N, Senda T, Murata T
Biochem Biophys Res Commun (2024) 709 pp. 149855-149855 [ DOI: doi:10.1016/j.bbrc.2024.149855 Pubmed: 38579618 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Atp-dependent translocase abcb1,mneongreen (170 kDa, Protein from Homo sapiens)
- Uic2 fab light chain (24 kDa, Protein from Mus musculus)
- Elacridar (563 Da, Ligand)
- Multidrug resistance protein (Complex from Homo sapiens)
- Uic2 fab heavy chain (24 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of K+-bound hERG channel
Asai T, Adachi N, Moriya T, Oki H, Maru T, Kawasaki M, Suzuki K, Chen S, Ishii R, Yonemori K, Igaki S, Yasuda S, Ogasawara S, Senda T, Murata T
Structure (2021) [ Pubmed: 33450182 DOI: 10.1016/j.str.2020.12.007 ]
Image sets:
Cryo-EM structure of K+-bound hERG channel in the presence of astemizole
Asai T, Adachi N, Moriya T, Oki H, Maru T, Kawasaki M, Suzuki K, Chen S, Ishii R, Yonemori K, Igaki S, Yasuda S, Ogasawara S, Senda T, Murata T
Structure (2021) [ Pubmed: 33450182 DOI: 10.1016/j.str.2020.12.007 ]
Image sets: