Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region
Human Kv4.2-KChIP2 channel complex in an intermediate state, transmembrane region
Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7ukf
Q-score: 0.478
Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH
Mol Cell (2022) 82 pp. 2427- [ Pubmed: 35597238 DOI: doi:10.1016/j.molcel.2022.04.032 ]
- Potassium voltage-gated channel subfamily d member 2 (59 kDa, Protein from Homo sapiens)
- Mercury (ii) ion (200 Da, Ligand)
- Human kv4.2-kchip2 channel complex in a putative resting state, transmembrane region (Complex from Homo sapiens)
- Potassium ion (39 Da, Ligand)
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region
Resolution: 2.24 Å
EM Method: Single-particle
Fitted PDBs: 7ukg
Q-score: 0.636
Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH
Mol Cell (2022) 82 pp. 2427- [ Pubmed: 35597238 DOI: doi:10.1016/j.molcel.2022.04.032 ]
- Potassium voltage-gated channel subfamily d member 2 (59 kDa, Protein from Homo sapiens)
- Human kv4.2-kchip2-dpp6 channel complex in an open state, transmembrane region (Complex from Homo sapiens)
- Dipeptidyl-peptidase 6 (91 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7ukh
Q-score: 0.607
Ye W, Zhao H, Dai Y, Wang Y, Lo YH, Jan LY, Lee CH
Mol Cell (2022) 82 pp. 2427- [ Pubmed: 35597238 DOI: doi:10.1016/j.molcel.2022.04.032 ]
- Potassium voltage-gated channel subfamily d member 2 (59 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Isoform 2 of kv channel-interacting protein 2 (28 kDa, Protein from Homo sapiens)
- Human kv4.2-kchip2-dpp6 channel complex in an open state, intracellular region (Complex from Homo sapiens)
CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 7s8l
Q-score: 0.602
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL
Nature (2021) 600 pp. 170-175 [ Pubmed: 34789874 DOI: doi:10.1038/s41586-021-04126-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cortistatin 14 (1 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Mrgprx2-gq cortistatin-14 (150 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 7s8m
Q-score: 0.562
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL
Nature (2021) 600 pp. 170-175 [ Pubmed: 34789874 DOI: doi:10.1038/s41586-021-04126-6 ]
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Mrgprx2-gi1 cortistatin-14 (150 MDa, Complex from Homo sapiens)
- Soluble cytochrome b562, mas-related g-protein coupled receptor member x2 chimera (54 kDa, Protein from Homo sapiens)
- Cortistatin 14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7s8n
Q-score: 0.579
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL
Nature (2021) 600 pp. 170-175 [ Pubmed: 34789874 DOI: doi:10.1038/s41586-021-04126-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mrgprx2-gq (r)-zinc-3573 (150 MDa, Complex from Homo sapiens)
- (3r)-n,n-dimethyl-1-[(8s)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine (307 Da, Ligand)
- Mas-related g-protein coupled receptor member x2 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)