Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ Pubmed: 35863378 DOI: 10.1038/s41586-022-05116-y ]
Image sets:
- Unaligned micrographs of IL-25 ternary complex at 35 degree tilt.
- Unaligned micrographs of IL-25 binary complex at 40 degree tilt.
- Unaligned micrographs of IL-25 binary complex at 0 degree tilt.
- Unaligned micrographs of IL-25 ternary complex at 0 degree tilt.
Structure of the homodimeric IL-25-IL-17RB binary complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7uwj
Q-score: 0.316
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Interleukin-25 (21 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-17 receptor b (28 kDa, Protein from Homo sapiens)
- Homodimeric il-25-il-17rb binary complex (Complex from Homo sapiens)
Structure of the higher-order IL-25-IL-17RB complex
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7uwk
Q-score: 0.165
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Higher-order il-25-il-17rb complex (Complex from Homo sapiens)
- Interleukin-25 (21 kDa, Protein from Homo sapiens)
- Interleukin-17 receptor b (33 kDa, Protein from Homo sapiens)
Structure of the IL-25-IL-17RB-IL-17RA ternary complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uwl
Q-score: 0.269
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Interleukin-25 (21 kDa, Protein from Homo sapiens)
- Interleukin-17 receptor b (33 kDa, Protein from Homo sapiens)
- Ternary il-25-il-17rb-il-17ra complex (Complex from Homo sapiens)
- Interleukin-17 receptor a (36 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the IL-17A-IL-17RA binary complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7uwm
Q-score: 0.536
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Interleukin-17 receptor a (31 kDa, Protein from Homo sapiens)
- Interleukin-17a (19 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Il-17a-il-17ra binary complex (Complex from Homo sapiens)
Structure of the IL-17A-IL-17RA-IL-17RC ternary complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 7uwn
Q-score: 0.316
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC
Nature (2022) 609 pp. 622-629 [ DOI: doi:10.1038/s41586-022-05116-y Pubmed: 35863378 ]
- Isoform 5 of interleukin-17 receptor c (53 kDa, Protein from Homo sapiens)
- Interleukin-17a (19 kDa, Protein from Homo sapiens)
- Il-17a-il-17ra-il-17rc ternary complex (Complex from Homo sapiens)
- Interleukin-17 receptor a (36 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)