Structure of NET-Maprotiline in outward-open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y8z
Q-score: 0.403
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- ~{n}-methyl-3-(1-tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9,11,13-hexaenyl)propan-1-amine (277 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
Structure of NET-Nefopam in outward-open state
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8y90
Q-score: 0.378
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- (1s)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (253 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
Structure of NET-nomifensine in outward-open state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8y91
Q-score: 0.447
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- (4s)-2-methyl-4-phenyl-3,4-dihydro-1h-isoquinolin-8-amine (238 Da, Ligand)
structure of NET-Atomoxetine in outward-open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y92
Q-score: 0.42
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- (3r)-n-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (255 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of NET-Amitriptyline in outward-open state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8y93
Q-score: 0.441
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Amitriptyline (277 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of Apo human norepinephrine transporter NET
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y94
Q-score: 0.364
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Structure of apo human net (100 kDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
Structure of NET-NE in Occluded state
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8y95
Q-score: 0.412
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter bound noradrenaline (Complex from Homo sapiens)
- Noradrenaline (170 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
Structure of NET-Nisoxetine in outward-open state
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8yr2
Q-score: 0.47
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(2r,3r,5s,6r)-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (586 Da, Ligand)
- Nisoxetine (271 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7eib
Q-score: 0.481
Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y
Nat Struct Mol Biol (2021) 28 pp. 755-761 [ DOI: doi:10.1038/s41594-021-00645-y Pubmed: 34518695 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the type 1 bradykinin receptor in complex with the des-arg10-kallidin and an gq protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- B1 bradykinin receptor (69 kDa, Protein from Homo sapiens)
- G subunit q (gi2-mini-gq chimeric) (Complex from Rattus norvegicus)
- Lys-arg-pro-pro-gly-phe-ser-pro-phe (1 kDa, Protein from Homo sapiens)
- Type 1 bradykinin receptor (Complex)
- Lys-arg-pro-pro-gly-phe-ser-pro-phe (Complex from Homo sapiens)
Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f2o
Q-score: 0.436
Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y
Nat Struct Mol Biol (2021) 28 pp. 755-761 [ Pubmed: 34518695 DOI: doi:10.1038/s41594-021-00645-y ]
- Type 2 bradykinin receptor (Complex from Homo sapiens)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- G subunit q (gi2-mini-gq chimeric) (Complex from Homo sapiens)
- Cryo-em structure of the type 2 bradykinin receptor in complex with the bradykinin and an gq protein (Complex from Homo sapiens)
- Single fab chain (svfv16) (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex)
- Single fab chain (svfv16) (Complex from Bos taurus)
- Arg-pro-pro-gly-phe-ser-pro-phe-arg (1 kDa, Protein from Homo sapiens)
- Arg-pro-pro-gly-phe-ser-pro-phe-arg (Complex from Rattus norvegicus)
- B2 bradykinin receptor (67 kDa, Protein from Homo sapiens)