Structure of NET-Maprotiline in outward-open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y8z
Q-score: 0.403
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- ~{n}-methyl-3-(1-tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2(7),3,5,9,11,13-hexaenyl)propan-1-amine (277 Da, Ligand)
Structure of NET-Nefopam in outward-open state
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8y90
Q-score: 0.378
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- (1s)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (253 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of NET-nomifensine in outward-open state
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8y91
Q-score: 0.447
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- (4s)-2-methyl-4-phenyl-3,4-dihydro-1h-isoquinolin-8-amine (238 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
structure of NET-Atomoxetine in outward-open state
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y92
Q-score: 0.42
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- (3r)-n-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (255 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of NET-Amitriptyline in outward-open state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8y93
Q-score: 0.441
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Amitriptyline (277 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Structure of Apo human norepinephrine transporter NET
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y94
Q-score: 0.364
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Structure of apo human net (100 kDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
Structure of NET-NE in Occluded state
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8y95
Q-score: 0.412
Zhang H, Yin YL, Dai A, Zhang T, Zhang C, Wu C, Hu W, He X, Pan B, Jin S, Yuan Q, Wang MW, Yang D, Xu HE, Jiang Y
Nature (2024) 630 pp. 247-254 [ DOI: doi:10.1038/s41586-024-07437-6 Pubmed: 38750358 ]
- Sodium-dependent noradrenaline transporter bound noradrenaline (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Noradrenaline (170 Da, Ligand)
- Sodium ion (22 Da, Ligand)