EM map Of Respiratory Syncytial Virus Polymerase in complex with JNJ-2729
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9c7y
Q-score: 0.502
Tran MT, Grosse S, Carbajo RJ, Jacoby E, Yin Y, Yu X, Martinez C, Stoops B, Cooymans L, Hu L, Lutter FH, Pieters S, Tan E, Alcazar J, Roymans D, van Vlijmen H, Rigaux P, Sharma S, Jonckers THM
Acs Med.Chem.Lett. (2024) 15 pp. 1549-1558 [ DOI: doi:10.1021/acsmedchemlett.4c00272 Pubmed: 39291020 ]
- (2s)-1,1,1-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-3-[(4m)-4-(8-methoxyquinolin-6-yl)-1h-1,2,3-triazol-1-yl]propan-2-ol (585 Da, Ligand)
- Respiratory syncytial virus polymerase in complex with non-nucleoside inhibitor (Complex from Human respiratory syncytial virus A2)
- Phosphoprotein (29 kDa, Protein from Human respiratory syncytial virus A2)
- Rna-directed rna polymerase l (254 kDa, Protein from Human respiratory syncytial virus A2)
Cryo-EM structure of prefusion-stabilized influenza B hemagglutinin
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8uad
Q-score: 0.598
Juraszek J, Milder FJ, Yu X, Blokland S, van Overveld D, Abeywickrema P, Tamara S, Sharma S, Rutten L, Bakkers MJG, Langedijk JPM
Pnas Nexus (2024) 3 pp. pgae462-pgae462 [ DOI: doi:10.1093/pnasnexus/pgae462 Pubmed: 39445049 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Prefusion-stabilized influenza b hemagglutinin (Complex from Influenza B virus)
- Hemagglutinin ha1 chain (38 kDa, Protein from Influenza B virus)
- Hemagglutinin ha2 chain (19 kDa, Protein from Influenza B virus)
Prefusion-stabilized trimer of FluB-HA under low pH conditions
Juraszek J, Milder FJ, Yu X, Blokland S, van Overveld D, Abeywickrema P, Tamara S, Sharma S, Rutten L, Bakkers MJG, Langedijk JPM
Pnas Nexus (2024) 3 pp. pgae462-pgae462 [ DOI: doi:10.1093/pnasnexus/pgae462 Pubmed: 39445049 ]
Cryo-EM structure of NLRP3 complex with Compound C
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 9dh3
Q-score: 0.348
Matico R, Grauwen K, Chauhan D, Yu X, Abdiaj I, Adhikary S, Adriaensen I, Aranzazu GM, Alcazar J, Bassi M, Brisse E, Canellas S, Chaudhuri S, Delgado F, Dieguez-Vazquez A, Du Jardin M, Eastham V, Finley M, Jacobs T, Keustermans K, Kuhn R, Llaveria J, Leenaerts J, Linares ML, Martin ML, Martin-Perez R, Martinez C, Miller R, Munoz FM, Muratore ME, Nooyens A, Perez-Benito L, Perrier M, Pietrak B, Serre J, Sharma S, Somers M, Suarez J, Tresadern G, Trabanco AA, Van den Bulck D, Van Gool M, Van Hauwermeiren F, Varghese T, Vega JA, Youssef SA, Edwards MJ, Oehlrich D, Van Opdenbosch N
Embo Mol Med (2025) 17 pp. 54-84 [ Pubmed: 39653810 DOI: doi:10.1038/s44321-024-00181-4 ]
- 2-[(4s)-5-ethyl-8-oxothieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-7(8h)-yl]-n-(pyrimidin-4-yl)acetamide (354 Da, Ligand)
- N-terminal mbp fusion of nlrp3 lacking the pyd domain (Complex from Homo sapiens)
- 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (614 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,nacht, lrr and pyd domains-containing protein 3 chimera (142 kDa, Protein from Homo sapiens)
Cryo-EM structure of inhibitor 25a bound human urea transporter A2.
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xd7
Q-score: 0.461
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
Cryo-EM structure of human urea transporter A2.
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xd9
Q-score: 0.547
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
- Homotrimer complex of human urea transporter (Complex from Homo sapiens)
- Urea transporter 2 (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of urea bound human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xda
Q-score: 0.54
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
- Water (18 Da, Ligand)
- Urea (60 Da, Ligand)
- Homotrimer complex of human urea transporter (Complex from Homo sapiens)
- Urea transporter 2 (43 kDa, Protein from Homo sapiens)
Cryo-EM structure of human urea transporter A2.
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8xdb
Q-score: 0.515
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
Cryo-EM structure of human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xdc
Q-score: 0.562
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
Cryo-EM structure of human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xdd
Q-score: 0.524
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
- 1-(3-methoxyphenyl)methanamine (137 Da, Ligand)
- Homotrimer complex of human urea transporter (Complex from Homo sapiens)
- Urea transporter 2 (43 kDa, Protein from Homo sapien)
- 8-hydroxyquinoline-2-carboxylic acid (189 Da, Ligand)