Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8gd9
Q-score: 0.534
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ DOI: doi:10.1073/pnas.2216329120 Pubmed: 37478163 ]
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 4-({2-[(1r,2r,3r,5s)-3,5-dihydroxy-2-{(3s)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid (440 Da, Ligand)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gda
Q-score: 0.506
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ DOI: doi:10.1073/pnas.2216329120 Pubmed: 37478163 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- (2s,5r)-5-[(1e,3s)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1h-tetrazol-5-yl)hexyl]pyrrolidin-2-ol (421 Da, Ligand)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8gdb
Q-score: 0.57
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ DOI: doi:10.1073/pnas.2216329120 Pubmed: 37478163 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gdc
Q-score: 0.401
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ DOI: doi:10.1073/pnas.2216329120 Pubmed: 37478163 ]
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep3 subtype (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gcm
Q-score: 0.482
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ DOI: doi:10.1073/pnas.2216329120 Pubmed: 37478163 ]
- Cryo-em structure of prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- (5s)-5-[(3r)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1h-tetrazol-5-yl)hexyl]pyrrolidin-2-one (421 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8gcp
Q-score: 0.463
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ DOI: doi:10.1073/pnas.2216329120 Pubmed: 37478163 ]
- Scfv (32 kDa, Protein from Homo sapiens)
- Cryo-em structure of prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Delta Spike protein in complex with BA7208 and BA7125 fab
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 7xdl
Q-score: 0.5
Wang Y, Yan A, Song D, Dong C, Rao M, Gao Y, Qi R, Ma X, Wang Q, Xu H, Liu H, Han J, Duan M, Liu S, Yu X, Zong M, Feng J, Jiao J, Zhang H, Li M, Yu B, Wang Y, Meng F, Ni X, Li Y, Shen Z, Sun B, Shao X, Zhao H, Zhao Y, Li R, Zhang Y, Du G, Lu J, You C, Jiang H, Zhang L, Wang L, Dou C, Liu Z, Zhao J
Cell Discov (2023) 9 pp. 3-3 [ Pubmed: 36609558 DOI: doi:10.1038/s41421-022-00509-9 ]
- Cryo-em structure of sars-cov-2 delta spike protein in complex with ba7208 and ba7125 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba7125 fab (22 kDa, Protein from Homo sapiens)
- Ba7208 and ba7125 fab (Complex)
- Ba7208 fab (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (123 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ba7208 fab (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 delta spike protein (Complex from Homo sapiens)
- Ba7125 fab (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7054 and BA7125 fab (local refinement)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7xcz
Q-score: 0.528
Wang Y, Yan A, Song D, Dong C, Rao M, Gao Y, Qi R, Ma X, Wang Q, Xu H, Liu H, Han J, Duan M, Liu S, Yu X, Zong M, Feng J, Jiao J, Zhang H, Li M, Yu B, Wang Y, Meng F, Ni X, Li Y, Shen Z, Sun B, Shao X, Zhao H, Zhao Y, Li R, Zhang Y, Du G, Lu J, You C, Jiang H, Zhang L, Wang L, Dou C, Liu Z, Zhao J
Cell Discov (2023) 9 pp. 3-3 [ Pubmed: 36609558 DOI: doi:10.1038/s41421-022-00509-9 ]
- Sars-cov-2 delta rbd (Complex from Homo sapiens)
- Cryo-em structure of sars-cov-2 delta rbd in complex with ba7054 and ba7125 fab (local refinement) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ba7125 fab (23 kDa, Protein from Homo sapiens)
- Ba7054 fab (23 kDa, Protein from Homo sapiens)
- Ba7054 fab (23 kDa, Protein from Homo sapiens)
- Ba7054 and ba7125 fab (Complex)
- Ba7125 fab (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with BA7208 and BA7125 fab (local refinement)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7xda
Q-score: 0.526
Wang Y, Yan A, Song D, Dong C, Rao M, Gao Y, Qi R, Ma X, Wang Q, Xu H, Liu H, Han J, Duan M, Liu S, Yu X, Zong M, Feng J, Jiao J, Zhang H, Li M, Yu B, Wang Y, Meng F, Ni X, Li Y, Shen Z, Sun B, Shao X, Zhao H, Zhao Y, Li R, Zhang Y, Du G, Lu J, You C, Jiang H, Zhang L, Wang L, Dou C, Liu Z, Zhao J
Cell Discov (2023) 9 pp. 3-3 [ Pubmed: 36609558 DOI: doi:10.1038/s41421-022-00509-9 ]
- Ba7208 fab (24 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 delta rbd in complex with ba7208 and ba7125 fab (local refinement) (Complex from Homo sapiens)
- Spike glycoprotein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ba7208 fab (23 kDa, Protein from Homo sapiens)
- Ba7125 fab (23 kDa, Protein from Homo sapiens)
- Ba7125 fab (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Omicron Spike protein in complex with BA7208 fab
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 7xdb
Q-score: 0.502
Wang Y, Yan A, Song D, Dong C, Rao M, Gao Y, Qi R, Ma X, Wang Q, Xu H, Liu H, Han J, Duan M, Liu S, Yu X, Zong M, Feng J, Jiao J, Zhang H, Li M, Yu B, Wang Y, Meng F, Ni X, Li Y, Shen Z, Sun B, Shao X, Zhao H, Zhao Y, Li R, Zhang Y, Du G, Lu J, You C, Jiang H, Zhang L, Wang L, Dou C, Liu Z, Zhao J
Cell Discov (2023) 9 pp. 3-3 [ Pubmed: 36609558 DOI: doi:10.1038/s41421-022-00509-9 ]
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba7208 fab (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron spike protein (Complex)
- Ba7208 fab (13 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron spike protein in complex with ba7208 fab (Complex from Homo sapiens)
- Ba7208 fab (Complex from Severe acute respiratory syndrome coronavirus 2)