SARS-CoV-2 DMV nsp3-4 pore complex (consensus-pore, C6 symmetry)
SARS-CoV-2 DMV nsp3-4 pore complex (consensus-pore, C3 symmetry)
Cryo-EM structure of the the 2-oxoglutarate dehydrogenase (E1) with TCAIM complex
Structure of NLRP3 and NEK7 complex
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 8sxn
Q-score: 0.33
Yu X, Matico RE, Miller R, Schoubroeck BV, Grauwen K, Suarez J, Pietrak B, Haloi N, Yin Y, Tresadern GJ, Perez-Benito L, Lindahl E, Bottelbergs A, Oehlrich D, Opdenbosch NV, Sharma S
Nat Commun (2024) [ ]
- 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (402 Da, Ligand)
- Covid spike variant deltan135 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Serine/threonine-protein kinase nek7 (34 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Nacht, lrr and pyd domains-containing protein 3 (103 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8fvu
Q-score: 0.412
Matico RE, Yu X, Miller R, Somani S, Ricketts MD, Kumar N, Steele RA, Medley Q, Berger S, Faustin B, Sharma S
Nat Struct Mol Biol (2024) 31 pp. 82-91 [ DOI: doi:10.1038/s41594-023-01143-z Pubmed: 38177670 ]
- Burkholderia needle (chimeric with an anthrax toxin lethal factor tag) (Complex from Bacillus anthracis)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Baculoviral iap repeat-containing protein 1 (160 kDa, Protein from Homo sapiens)
- Nlr family card domain-containing protein 4 (116 kDa, Protein from Homo sapiens)
- The complex of needle, human naip and nlrc4 (Complex)
- Human naip and nlrc4 (Complex from Homo sapiens)
- Lethal factor,type iii secretion system protein (42 kDa, Protein from Burkholderia)
- Zinc ion (65 Da, Ligand)
T1AM-bound hTAAR1-Gs protein complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8jln
Q-score: 0.427
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- T1am-bound htaar1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Mgs (43 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- Gs heterotrimer (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
A77636-bound hTAAR1-Gs protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jlr
Q-score: 0.462
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Mgs (41 kDa, Protein from Homo sapiens)
- Htaar1-bound a77636 in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- (1~{s},3~{r})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{h}-isochromene-5,6-diol (329 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- Gs heterotrimer (Complex from Homo sapiens)
- A7736-bound htaar1 (Complex from Homo sapiens)
Structure of SARS-CoV-2 Omicron BA.1 spike in complex with antibody Fab 1C3
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8f0g
Q-score: 0.469
Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Saphire EO
Cell Rep (2023) 42 pp. 112421-112421 [ DOI: doi:10.1016/j.celrep.2023.112421 Pubmed: 37083327 ]
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody 1c3 fab light chain (11 kDa, Protein from Homo sapiens)
- Antibody 1c3 fab heavy chain,antibody 1c3 fab light chain (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody 1c3 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of sars-cov-2 omicron ba.1 spike in complex with antibody 1c3 fab (Complex)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8f0h
Q-score: 0.484
Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Saphire EO
Cell Rep (2023) 42 pp. 112421-112421 [ Pubmed: 37083327 DOI: doi:10.1016/j.celrep.2023.112421 ]
- Antibody fab 2a10 light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody fab 1h2 heavy chain (13 kDa, Protein from Homo sapiens)
- Antibody fab 1h2 heavy chain, antibody fab 1h2 light chain, antibody fab 2a10 heavy chain, antibody fab 2a10 light chain (Complex from Homo sapiens)
- Antibody fab 1h2 light chain (10 kDa, Protein from Homo sapiens)
- Structure of sars-cov-2 d614g spike in complex with antibody fabs 1h2 and 2a10 (Complex)
- Antibody fab 2a10 heavy chain (12 kDa, Protein from Homo sapiens)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)