Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7zpj
Q-score: -0.01
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P
Mol Cell (2022) 82 pp. 4064-4079.e13 [ DOI: doi:10.1016/j.molcel.2022.10.010 Pubmed: 36332606 ]
- Pre-dicing state of mouse somatic dicer with pre-mir-15a and tarbp2 (Complex)
- Risc-loading complex subunit tarbp2 isoform 1 (39 kDa, Protein from Mus musculus)
- 59-nt precursor of mir-15a (19 kDa, RNA from Mus musculus)
- Endoribonuclease dicer (226 kDa, Protein from Mus musculus)
- Pre-mir-15a (Complex from Mus musculus)
- Pre-dicing state of mouse somatic dicer with tarbp2 (Complex from Mus musculus)
Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate
Resolution: 4.19 Å
EM Method: Single-particle
Fitted PDBs: 7yym
Q-score: 0.192
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P
Mol Cell (2022) 82 pp. 4064-4079.e13 [ DOI: doi:10.1016/j.molcel.2022.10.010 Pubmed: 36332606 ]
- Endoribonuclease dicer (226 kDa, Protein from Mus musculus)
- Pre-mir-15a (Complex from synthetic construct)
- 59-nt precursor of mir-15a (19 kDa, RNA from synthetic construct)
- Pre-dicing state of mouse somatic dicer (Complex from Mus musculus)
- Pre-dicing state of mouse somatic dicer with pre-mir-15a (Complex)
Mammalian Dicer in the dicing state with pre-miR-15a substrate
Resolution: 6.21 Å
EM Method: Single-particle
Fitted PDBs: 7yyn
Q-score: 0.133
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P
Mol Cell (2022) 82 pp. 4064-4079.e13 [ DOI: doi:10.1016/j.molcel.2022.10.010 Pubmed: 36332606 ]
- Isoform 2 of endoribonuclease dicer (200 kDa, Protein from Mus musculus)
- 59-nt precursor of mir-15a (Complex from Mus musculus)
- Isoform 2 of endoribonuclease dicer (Complex from Mus musculus)
- 59-nt precursor of mir-15a (19 kDa, RNA from Mus musculus)
- Dicing state of mouse oocyte dicer with pre-mir-15a (Complex)
Mouse endoribonuclease Dicer (composite structure)
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 7yz4
Q-score: 0.293
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P
Mol Cell (2022) 82 pp. 4064-4079.e13 [ DOI: doi:10.1016/j.molcel.2022.10.010 Pubmed: 36332606 ]
- Free form of mouse somatic dicer (Cellular component from Mus musculus)
- Endoribonuclease dicer (226 kDa, Protein from Mus musculus)
Mammalian Dicer in the "dicing state" with pre-miR-15a substrate
Resolution: 5.91 Å
EM Method: Single-particle
Fitted PDBs: 7zpi
Q-score: 0.106
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P
Mol Cell (2022) 82 pp. 4064-4079.e13 [ DOI: doi:10.1016/j.molcel.2022.10.010 Pubmed: 36332606 ]
- Dicing state of mouse somatic dicer (Complex from Mus musculus)
- 59-nt precursor of mir-15a (19 kDa, RNA from Mus musculus)
- Endoribonuclease dicer (226 kDa, Protein from Mus musculus)
- Dicing state of mouse somatic dicer with pre-mir-15a (Complex)
- Pre-mir-15a (Complex from Mus musculus)
Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7zpk
Q-score: 0.112
Zapletal D, Taborska E, Pasulka J, Malik R, Kubicek K, Zanova M, Much C, Sebesta M, Buccheri V, Horvat F, Jenickova I, Prochazkova M, Prochazka J, Pinkas M, Novacek J, Joseph DF, Sedlacek R, Bernecky C, O'Carroll D, Stefl R, Svoboda P
Mol Cell (2022) 82 pp. 4064-4079.e13 [ DOI: doi:10.1016/j.molcel.2022.10.010 Pubmed: 36332606 ]
- Pre-dicing state of mouse somatic dicer with pre-mir-15a and tarbp2 (Complex)
- 59-nt precursor of mir-15a (19 kDa, RNA from Mus musculus)
- Endoribonuclease dicer (226 kDa, Protein from Mus musculus)
- Risc-loading complex subunit tarbp2 (39 kDa, Protein from Mus musculus)
- Pre-mir-15a (Complex from Mus musculus)
- Pre-dicing state of mouse somatic dicer with tarbp2 (Complex from Mus musculus)
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7o6b
Q-score: 0.296
Kasiliauskaite A, Kubicek K, Klumpler T, Zanova M, Zapletal D, Koutna E, Novacek J, Stefl R
Nucleic Acids Res (2022) 50 pp. 5961-5973 [ DOI: doi:10.1093/nar/gkac451 Pubmed: 35640611 ]