Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8c1p
Q-score: 0.561
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Water (18 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Cyclothiazide (389 Da, Ligand)
Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8c1q
Q-score: 0.54
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Water (18 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c1r
Q-score: 0.55
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Water (18 Da, Ligand)
- Homomeric glua2 f231a mutant ampa receptor in complex with tarp gamma 2 (Complex from Rattus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8c1s
Q-score: 0.556
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Water (18 Da, Ligand)
- Glutamate receptor 2 (99 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- Homomeric glua2 f231a mutant ampa receptor in complex with tarp gamma 2 (Complex from Rattus)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8c2h
Q-score: 0.619
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Water (18 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8c2i
Q-score: 0.581
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 (Complex from Rattus)
- Water (18 Da, Ligand)
- Voltage-dependent calcium channel gamma-3 subunit (35 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Glutamate receptor 1 flip isoform (102 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8p3q
Q-score: 0.357
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Water (18 Da, Ligand)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)
- Homomeric glua1 ampa receptor in complex with tarp gamma 3 and 1mm quisqualate (Complex from Rattus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8p3s
Q-score: 0.361
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Water (18 Da, Ligand)
- Glutamate receptor 2 (98 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-2 subunit (35 kDa, Protein from Rattus norvegicus)
- Glua2 irr f231a mutant ampa receptor (r/g unedited) in tandem with tarp gamma 2 in complex with 1mm quisqualate (Complex from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 1
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8p3t
Q-score: 0.334
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]
Homomeric GluA1 in tandem with TARP gamma-3, desensitized conformation 2
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8p3u
Q-score: 0.273
Zhang D, Ivica J, Krieger JM, Ho H, Yamashita K, Stockwell I, Baradaran R, Cais O, Greger IH
Nature (2023) 621 pp. 877-882 [ Pubmed: 37704721 DOI: doi:10.1038/s41586-023-06528-0 ]