Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7oca
Q-score: 0.525
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- Cholesterol (386 Da, Ligand)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Glua1/a2 heterotertramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
NTD of resting state GluA1/A2 heterotertramer
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7occ
Q-score: 0.511
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ DOI: doi:10.1038/s41586-021-03613-0 Pubmed: 34079129 ]
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glua1/a2 heterotertramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (Complex from Rattus norvegicus)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ocd
Q-score: 0.495
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ DOI: doi:10.1038/s41586-021-03613-0 Pubmed: 34079129 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Glua1/a2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (Complex from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7oce
Q-score: 0.541
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ Pubmed: 34079129 DOI: doi:10.1038/s41586-021-03613-0 ]
- Cholesterol (386 Da, Ligand)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Glua1/a2 heterotetramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7ocf
Q-score: 0.465
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ DOI: doi:10.1038/s41586-021-03613-0 Pubmed: 34079129 ]
- Glua1/a2 heterotetramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Cyclothiazide (389 Da, Ligand)