Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ayl
Q-score: 0.511
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (443 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Resting state glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-61432059 (Complex from Rattus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8aym
Q-score: 0.472
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-55511118 (Complex from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1h-benzimidazol-2-ol (328 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ayn
Q-score: 0.558
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- 6-[(1~{s})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{h}-1,3-benzothiazol-2-one (382 Da, Ligand)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand ly3130481 (Complex from Rattus norvegicus)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ayo
Q-score: 0.498
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (443 Da, Ligand)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-61432059 (Complex from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Cyclothiazide (389 Da, Ligand)
Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7qhb
Q-score: 0.453
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Palmitoleic acid (254 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- (2s)-2,3-dihydroxypropyl (7z)-hexadec-7-enoate (328 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Cyclothiazide (389 Da, Ligand)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7qhh
Q-score: 0.359
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Palmitoleic acid (254 Da, Ligand)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- (2s)-2,3-dihydroxypropyl (7z)-hexadec-7-enoate (328 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)