Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8sbd
Q-score: 0.466
Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC
Sci Adv (2023) 9 pp. eadi1057-eadi1057 [ DOI: doi:10.1126/sciadv.adi1057 Pubmed: 37713485 ]
Cryo-EM structure of a synaptobrevin-Munc18-1-syntaxin-1 complex class 2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7udb
Q-score: 0.491
Stepien KP, Xu J, Zhang X, Bai XC, Rizo J
Sci Adv (2022) 8 pp. eabo5272-eabo5272 [ DOI: doi:10.1126/sciadv.abo5272 Pubmed: 35731863 ]
- Syntaxin-binding protein 1 (68 kDa, Protein from Rattus norvegicus)
- Syntaxin-1a (29 kDa, Protein from Rattus norvegicus)
- Ternary complex of munc18-1 bound to syntaxin-1a and a snare motif of synaptobrevin 2 (Complex from Rattus norvegicus)
- Synaptobrevin-2 (6 kDa, Protein from Rattus norvegicus)
cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex class1
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7udc
Q-score: 0.466
Stepien KP, Xu J, Zhang X, Bai XC, Rizo J
Sci Adv (2022) 8 pp. eabo5272-eabo5272 [ DOI: doi:10.1126/sciadv.abo5272 Pubmed: 35731863 ]
- Syntaxin-binding protein 1 (68 kDa, Protein from Rattus norvegicus)
- Syntaxin-1a (29 kDa, Protein from Rattus norvegicus)
- Ternary complex of munc18-1 bound to syntaxin-1a and a snare motif of synaptobrevin 2 (Complex from Rattus norvegicus)
- Synaptobrevin-2 (6 kDa, Protein from Rattus norvegicus)
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl1
Q-score: 0.433
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ DOI: doi:10.1038/s41594-022-00750-6 Pubmed: 35361965 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e) (Complex)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sl2
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation (Complex)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl3
Q-score: 0.417
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation (Complex)
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7sl4
Q-score: 0.258
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation (Complex)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7sl6
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- symmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sl7
Q-score: 0.412
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (l13r) (2 kDa, Protein from Homo sapiens)
- Insulin a chain (v3e) (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-v3e) and site 2 binding deficient mutant insulin (a-l13r) (Complex)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7sth
Q-score: 0.415
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ DOI: doi:10.1038/s41594-022-00750-6 Pubmed: 35361965 ]
- Insulin (11 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with unsaturated insulin wt (2 insulin bound) symmetric conformation (Complex from Mus musculus)