Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8flk
Q-score: 0.438
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ DOI: doi:10.1038/s41589-023-01434-y Pubmed: 37828400 ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Cgamp (674 Da, Ligand)
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ DOI: doi:10.1038/s41589-023-01434-y Pubmed: 37828400 ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Cgamp (674 Da, Ligand)
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8sbd
Q-score: 0.466
Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC
Sci Adv (2023) 9 pp. eadi1057-eadi1057 [ DOI: doi:10.1126/sciadv.adi1057 Pubmed: 37713485 ]
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl1
Q-score: 0.433
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ DOI: doi:10.1038/s41594-022-00750-6 Pubmed: 35361965 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e) (Complex)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sl2
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation (Complex)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl3
Q-score: 0.417
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation (Complex)
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7sl4
Q-score: 0.258
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation (Complex)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7sl6
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- symmetric conformation (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sl7
Q-score: 0.412
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (l13r) (2 kDa, Protein from Homo sapiens)
- Insulin a chain (v3e) (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-v3e) and site 2 binding deficient mutant insulin (a-l13r) (Complex)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7sth
Q-score: 0.415
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ DOI: doi:10.1038/s41594-022-00750-6 Pubmed: 35361965 ]
- Insulin (11 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with unsaturated insulin wt (2 insulin bound) symmetric conformation (Complex from Mus musculus)