Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8flk
Q-score: 0.438
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ DOI: doi:10.1038/s41589-023-01434-y Pubmed: 37828400 ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Cgamp (674 Da, Ligand)
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ DOI: doi:10.1038/s41589-023-01434-y Pubmed: 37828400 ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Cgamp (674 Da, Ligand)
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8sbd
Q-score: 0.466
Wang L, Hall CE, Uchikawa E, Chen D, Choi E, Zhang X, Bai XC
Sci Adv (2023) 9 pp. eadi1057-eadi1057 [ DOI: doi:10.1126/sciadv.adi1057 Pubmed: 37713485 ]
FAM46C/BCCIPalpha/Nanobody complex
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 8eqb
Q-score: 0.125
Liu S, Chen H, Yin Y, Lu D, Gao G, Li J, Bai XC, Zhang X
Sci Adv (2023) 9 pp. eadf5583-eadf5583 [ Pubmed: 37018411 DOI: doi:10.1126/sciadv.adf5583 ]
- The complex between fam46c and bccipalpha (300 kDa, Complex from Homo sapiens)
- Synthetic nanobody 1 (13 kDa, Protein from Lama glama)
- Terminal nucleotidyltransferase 5c (24 kDa, Protein from Homo sapiens)
- Isoform 2 of brca2 and cdkn1a-interacting protein (28 kDa, Protein from Homo sapiens)
Cryo-EM structure of a synaptobrevin-Munc18-1-syntaxin-1 complex class 2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7udb
Q-score: 0.491
Stepien KP, Xu J, Zhang X, Bai XC, Rizo J
Sci Adv (2022) 8 pp. eabo5272-eabo5272 [ DOI: doi:10.1126/sciadv.abo5272 Pubmed: 35731863 ]
- Syntaxin-binding protein 1 (68 kDa, Protein from Rattus norvegicus)
- Syntaxin-1a (29 kDa, Protein from Rattus norvegicus)
- Ternary complex of munc18-1 bound to syntaxin-1a and a snare motif of synaptobrevin 2 (Complex from Rattus norvegicus)
- Synaptobrevin-2 (6 kDa, Protein from Rattus norvegicus)
cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex class1
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7udc
Q-score: 0.466
Stepien KP, Xu J, Zhang X, Bai XC, Rizo J
Sci Adv (2022) 8 pp. eabo5272-eabo5272 [ DOI: doi:10.1126/sciadv.abo5272 Pubmed: 35731863 ]
- Syntaxin-binding protein 1 (68 kDa, Protein from Rattus norvegicus)
- Syntaxin-1a (29 kDa, Protein from Rattus norvegicus)
- Ternary complex of munc18-1 bound to syntaxin-1a and a snare motif of synaptobrevin 2 (Complex from Rattus norvegicus)
- Synaptobrevin-2 (6 kDa, Protein from Rattus norvegicus)
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl1
Q-score: 0.433
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e) (Complex)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sl2
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation (Complex)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl3
Q-score: 0.417
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation (Complex)
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7sl4
Q-score: 0.258
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation (Complex)