Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7sii
Q-score: 0.491
Lu D, Shang G, Li J, Lu Y, Bai XC, Zhang X
Nature (2022) 604 pp. 557-562 [ DOI: doi:10.1038/s41586-022-04559-7 Pubmed: 35388221 ]
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Cgamp (674 Da, Ligand)
- Human sting (Complex from Homo sapiens)
Cryo-EM structure of the Sema3A/PlexinA4/Neuropilin 1 complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7m0r
Q-score: 0.33
Lu D, Shang G, He X, Bai XC, Zhang X
Nat Commun (2021) 12 pp. 3172-3172 [ DOI: doi:10.1038/s41467-021-23541-x Pubmed: 34039996 ]
- Calcium ion (40 Da, Ligand)
- Plexin-a4 (133 kDa, Protein from Mus musculus)
- Neuropilin-1 (64 kDa, Protein from Mus musculus)
- Semaphorin-3a (67 kDa, Protein from Mus musculus)
- Ternary complex of sema3a, plexina4 and neuropilin 1 (600 MDa, Complex from Mus musculus)
Cryo-EM Structure of the full-length A39R/PlexinC1 complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6vxk
Q-score: 0.512
Kuo YC, Chen H, Shang G, Uchikawa E, Tian H, Bai XC, Zhang X
Nat Commun (2020) 11 pp. 1953-1953 [ DOI: doi:10.1038/s41467-020-15862-0 Pubmed: 32327662 ]
- Plexin-c1 (173 kDa, Protein from Homo sapiens)
- Semaphorin-like protein 139 (45 kDa, Protein from Ectromelia virus (strain Moscow))
- Plexinc1 (Complex from Homo sapiens)
- Complex between a39r and plexinc1 (400 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- A39r dimer (Complex from Ectromelia virus)
Cryo-EM structure of extracellular dimeric complex of RET/GFRAL/GDF15
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6q2j
Q-score: 0.111
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Gdnf family receptor alpha-like (39 kDa, Protein from Homo sapiens)
- Growth/differentiation factor 15 (14 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
Cryo-EM structure of RET/GFRa1/GDNF extracellular complex
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6q2n
Q-score: 0.223
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Glial cell line-derived neurotrophic factor (15 kDa, Protein from Homo sapiens)
- Gdnf family receptor alpha-1 (46 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 6q2o
Q-score: 0.062
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Neurturin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gdnf family receptor alpha-2 (39 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6q2r
Q-score: 0.134
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Neurturin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gdnf family receptor alpha-2 (39 kDa, Protein from Homo sapiens)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6q2s
Q-score: 0.208
Li J, Shang G, Chen YJ, Brautigam CA, Liou J, Zhang X, Bai XC
eLife (2019) 8 [ Pubmed: 31535977 DOI: doi:10.7554/eLife.47650 ]
- Proto-oncogene tyrosine-protein kinase receptor ret (69 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Gdnf family receptor alpha-3 (38 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein smt3,artemin (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ret, gfral and gdf15 extracellular complex (200 MDa, Complex from Homo sapiens)