Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8z7r
Q-score: 0.517
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ Pubmed: 39738067 DOI: doi:10.1038/s41467-024-55359-8 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
SLC19A3-thiamine outward structure
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8z7s
Q-score: 0.541
SLC19A3-Pyridoxine outward structure
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8z7t
Q-score: 0.492
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ Pubmed: 39738067 DOI: doi:10.1038/s41467-024-55359-8 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
SLC19A3-Fedratinib outward structure
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8z7u
Q-score: 0.535
Slc19A3-Amprolium outward structure
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8z7v
Q-score: 0.497
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ Pubmed: 39738067 DOI: doi:10.1038/s41467-024-55359-8 ]
- Amprolium (243 Da, Ligand)
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
SLC19A3-Metformin outward structure
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8z7w
Q-score: 0.533
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ Pubmed: 39738067 DOI: doi:10.1038/s41467-024-55359-8 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Metformin (129 Da, Ligand)
- Slc19a3 (Complex from Homo sapiens)
SLC19A3-Thiamine inward structure
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8z7x
Q-score: 0.443
SLC19A3-Fedratinib inward structure
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8z7y
Q-score: 0.484
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xpz
Q-score: 0.508
Zhang Q, Zhang X, Zhu Y, Sun P, Zhang L, Ma J, Zhang Y, Zeng L, Nie X, Gao Y, Li Z, Liu S, Lou J, Gao A, Zhang L, Gao P
Nature (2022) 612 pp. 170-176 [ DOI: doi:10.1038/s41586-022-05452-z Pubmed: 36265513 ]
- Reduced folate transporter (60 kDa, Protein from Homo sapiens)
- Slc19a1 (Complex from Homo sapiens)
Structure of hSLC19A1+3'3'-CDA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7xq0
Q-score: 0.558
Zhang Q, Zhang X, Zhu Y, Sun P, Zhang L, Ma J, Zhang Y, Zeng L, Nie X, Gao Y, Li Z, Liu S, Lou J, Gao A, Zhang L, Gao P
Nature (2022) 612 pp. 170-176 [ DOI: doi:10.1038/s41586-022-05452-z Pubmed: 36265513 ]
- Reduced folate transporter (60 kDa, Protein from Homo sapiens)
- Slc19a1+3'3'-cda (Complex from Homo sapiens)
- (2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide (658 Da, Ligand)