Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8xjn
Q-score: 0.509
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ DOI: doi:10.1016/j.celrep.2024.113893 Pubmed: 38446662 ]
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cloprosetnol-tp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Cloprostenol (424 Da, Ligand)
- Fusion tag,thromboxane a2 receptor,lgbit (61 kDa, Protein from synthetic construct)
U46619 bound Thromboxane A2 receptor-Gq Protein Complex
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8xjo
Q-score: 0.493
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ DOI: doi:10.1016/j.celrep.2024.113893 Pubmed: 38446662 ]
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- (5z)-7-{(1r,4s,5s,6r)-6-[(1e,3s)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid (350 Da, Ligand)
- Fusion tag,thromboxane a2 receptor,lgbit (61 kDa, Protein from synthetic construct)
- U46619-tp-minigq-scfv16 complex (Complex from Homo sapiens)
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8g05
Q-score: 0.524
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C
Nat Commun (2023) 14 pp. 5706-5706 [ DOI: doi:10.1038/s41467-023-41201-0 Pubmed: 37709767 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 6oau_gpr84_dngi_scfv16 (Complex from Spodoptera frugiperda)
- G-protein coupled receptor 84 (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- 6-(octylamino)pyrimidine-2,4(3h,5h)-dione (239 Da, Ligand)