Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ore
Q-score: 0.593
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8orf
Q-score: 0.601
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8org
Q-score: 0.606
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7zi4
Q-score: 0.462
Vance NR, Ayala R, Willhoft O, Tvardovskiy A, McCormack EA, Bartke T, Zhang X, Wigley DB
To Be Published
- Ruvb-like 1 (50 kDa, Protein from Homo sapiens)
- Histone h2b type 1-j (13 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Actin-related protein 5 (68 kDa, Protein from Homo sapiens)
- Histone h2a type 1-b/e (14 kDa, Protein from Homo sapiens)
- Dna (158-mer) (48 kDa, DNA from synthetic construct)
- Ino80 complex subunit c (20 kDa, Protein from Homo sapiens)
- Dna (158-mer) (48 kDa, DNA from synthetic construct)
- Ruvb-like 2 (51 kDa, Protein from Homo sapiens)
- Chromatin-remodeling atpase ino80 (177 kDa, Protein from Homo sapiens)
- Ino80 complex subunit b (38 kDa, Protein from Homo sapiens)
- Beryllium trifluoride ion (66 Da, Ligand)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Complex of human ino80core bound to a wt nucleosome (1 MDa, Complex from Homo sapiens)
Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7qtq
Q-score: 0.502
Marechal N, Serrano BP, Zhang X, Weitz CJ
Nat Commun (2022) 13 pp. 2380-2380 [ Pubmed: 35501346 DOI: doi:10.1038/s41467-022-30082-4 ]
PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7lci
Q-score: 0.428
Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ
Structure (2021) 29 pp. 963- [ Pubmed: 33957078 DOI: doi:10.1016/j.str.2021.04.008 ]
- Glp-1:gs complex with small molecule agonist bound (pf-06882961) (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2s)-oxetan-2-yl]methyl}-1h-benzimidazole-6-carboxylic acid (555 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 7lcj
Q-score: 0.533
Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ
Structure (2021) 29 pp. 963- [ Pubmed: 33957078 DOI: doi:10.1016/j.str.2021.04.008 ]
- 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2s)-oxetan-2-yl]methyl}-1h-benzimidazole-6-carboxylic acid (555 Da, Ligand)
- Receptor only portion of glp1:gs complex with a small molecule agonist bound: pf-06882961 (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 6z2w
Q-score: 0.479
Tannous EA, Yates LA, Zhang X, Burgers PM
Nat Struct Mol Biol (2021) 28 pp. 50-61 [ Pubmed: 33169019 DOI: doi:10.1038/s41594-020-00522-0 ]
- Dna damage checkpoint protein lcd1 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Mec1-ddc2 (720 kDa, Complex from Saccharomyces cerevisiae S288C)
- Serine/threonine-protein kinase mec1 (273 kDa, Protein from Saccharomyces cerevisiae S288C)
Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP (State II)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6z2x
Q-score: 0.418
Tannous EA, Yates LA, Zhang X, Burgers PM
Nat Struct Mol Biol (2021) 28 pp. 50-61 [ DOI: doi:10.1038/s41594-020-00522-0 Pubmed: 33169019 ]
- Mec1-ddc2 (720 kDa, Complex from Saccharomyces cerevisiae S288C)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Serine/threonine-protein kinase mec1 (273 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna damage checkpoint protein lcd1 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
- Zinc ion (65 Da, Ligand)
Mec1-Ddc2 (wild-type) in complex with AMP-PNP
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6z3a
Q-score: 0.257
Tannous EA, Yates LA, Zhang X, Burgers PM
Nat Struct Mol Biol (2021) 28 pp. 50-61 [ Pubmed: 33169019 DOI: doi:10.1038/s41594-020-00522-0 ]
- Dna damage checkpoint protein lcd1 (86 kDa, Protein from Saccharomyces cerevisiae S288C)
- Serine/threonine-protein kinase mec1 (273 kDa, Protein from Saccharomyces cerevisiae S288C)
- Zinc ion (65 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Mec1-ddc2 (720 kDa, Complex from Saccharomyces cerevisiae S288C)