Plasmodium falciparum 20S proteasome bound to an inhibitor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2f
Q-score: 0.576
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA
Cell Chem Biol (2024) 31 pp. 1503- [ Pubmed: 39084225 DOI: doi:10.1016/j.chembiol.2024.07.001 ]
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type-3, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (33 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (26 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome bound with an inhibitor (750 kDa, Complex from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (28 kDa, Protein from Plasmodium falciparum 3D7)
- (3s)-1-[(2-fluoroethoxy)acetyl]-n-{[(4p)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide (420 Da, Ligand)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type (23 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type-6, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
Cryo-EM structure of 6-subunit Smc5/6 arm region
Resolution: 6.02 Å
EM Method: Single-particle
Fitted PDBs: 8i21
Q-score: 0.127
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cryo-em structure of 6-subunit smc5/6 arm region (Complex from Saccharomyces cerevisiae)
- E3 sumo-protein ligase mms21 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of 5-subunit Smc5/6 hinge region
Resolution: 6.73 Å
EM Method: Single-particle
Fitted PDBs: 8i4u
Q-score: 0.189
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cryo-em structure of 5-subunit smc5/6 hinge region (Complex from Saccharomyces cerevisiae S288c)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- E3 sumo-protein ligase mms21 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of 5-subunit Smc5/6 arm region
Resolution: 5.97 Å
EM Method: Single-particle
Fitted PDBs: 8i4v
Q-score: 0.108
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ DOI: doi:10.1038/s41594-024-01319-1 Pubmed: 38890552 ]
- E3 sumo-protein ligase mms21 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (123 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cryo-em structure of 5-subunit smc5/6 arm region (Complex from Saccharomyces cerevisiae)
- Dna repair protein kre29 (7 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of 5-subunit Smc5/6 head region
Resolution: 6.01 Å
EM Method: Single-particle
Fitted PDBs: 8i4w
Q-score: 0.067
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- Cryo-em structure of 5-subunit smc5/6 head region (Complex from Saccharomyces cerevisiae S288c)
- Dna repair protein kre29 (53 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosome element 5 (64 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of 5-subunit Smc5/6
Resolution: 8.5 Å
EM Method: Single-particle
Fitted PDBs: 8i4x
Q-score: 0.019
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- Structural maintenance of chromosomes protein 5 (123 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- Nse6 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosome element 5 (64 kDa, Protein from Saccharomyces cerevisiae S288C)
- E3 sumo-protein ligase mms21 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cryo-em structure of 5-subunit smc5/6 (Complex from Saccharomyces cerevisiae S288C)
Cryo-EM structure of 6-subunit Smc5/6 hinge region
Resolution: 6.15 Å
EM Method: Single-particle
Fitted PDBs: 8wjl
Q-score: 0.189
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- 6-subunit smc5/6 complex (Complex from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- E3 sumo-protein ligase mms21 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Cryo-EM structure of 6-subunit Smc5/6 head region
Resolution: 5.58 Å
EM Method: Single-particle
Fitted PDBs: 8wjn
Q-score: 0.198
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- Non-structural maintenance of chromosomes element 1 (38 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosomes element 4 (46 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosome element 3 (34 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cryo-em structure of 6-subunit smc5/6 head region (Complex from Saccharomyces cerevisiae)
Cryo-EM structure of 8-subunit Smc5/6 arm region
Resolution: 6.04 Å
EM Method: Single-particle
Fitted PDBs: 8wjo
Q-score: 0.171
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ DOI: doi:10.1038/s41594-024-01319-1 Pubmed: 38890552 ]
- E3 sumo-protein ligase mms21 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna repair protein kre29 (53 kDa, Protein from Saccharomyces cerevisiae S288C)
- Cryo-em structure of 8-subunit smc5/6 arm region (98 MDa, Complex from Saccharomyces cerevisiae)
Cryo-EM structure of 8-subunit Smc5/6 head region
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hqs
Q-score: 0.247
Li Q, Zhang J, Haluska C, Zhang X, Wang L, Liu G, Wang Z, Jin D, Cheng T, Wang H, Tian Y, Wang X, Sun L, Zhao X, Chen Z, Wang L
Nat Struct Mol Biol (2024) 31 pp. 1532-1542 [ Pubmed: 38890552 DOI: doi:10.1038/s41594-024-01319-1 ]
- Cryo-em structure of 8-subunit smc5/6 head region (Complex from Saccharomyces cerevisiae)
- Dna repair protein kre29 (53 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosomes element 1 (38 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 5 (126 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosome element 4 (46 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosome element 3 (34 kDa, Protein from Saccharomyces cerevisiae S288C)
- Non-structural maintenance of chromosome element 5 (64 kDa, Protein from Saccharomyces cerevisiae S288C)
- Structural maintenance of chromosomes protein 6 (128 kDa, Protein from Saccharomyces cerevisiae S288C)