Cryo-EM structure of human HGSNAT bound with Acetyl-CoA
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8vkj
Q-score: 0.562
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ DOI: doi:10.1038/s41467-024-49614-1 Pubmed: 38918376 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
Cryo-EM structure of human HGSNAT bound with Acetyl-CoA and substrate analog
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8vlg
Q-score: 0.523
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ DOI: doi:10.1038/s41467-024-49614-1 Pubmed: 38918376 ]
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- 4-methyl-2-oxo-2h-1-benzopyran-7-yl 2-amino-2-deoxy-beta-d-glucopyranoside (337 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
Cryo-EM structure of human HGSNAT bound with CoA and product analog
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vli
Q-score: 0.513
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ DOI: doi:10.1038/s41467-024-49614-1 Pubmed: 38918376 ]
- 4-methyl-2-oxo-2h-1-benzopyran-7-yl 2-acetamido-2-deoxy-beta-d-glucopyranoside (379 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
Cryo-EM structure of human HGSNAT bound with CoA
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8vlu
Q-score: 0.533
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ DOI: doi:10.1038/s41467-024-49614-1 Pubmed: 38918376 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
Cryo-EM structure of human HGSNAT in inactive state
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8vlv
Q-score: 0.484
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ DOI: doi:10.1038/s41467-024-49614-1 Pubmed: 38918376 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Purified human hgsnat (73 kDa, Cellular component from Homo sapiens)
Cryo-EM structure of human HGSNAT in transition state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8vly
Q-score: 0.494
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ DOI: doi:10.1038/s41467-024-49614-1 Pubmed: 38918376 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Purified human hgsnat (73 kDa, Cellular component from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7y04
Q-score: 0.49
Wen Z, Zhang Y, Zhang B, Hang Y, Xu L, Chen Y, Xie Q, Zhao Q, Zhang L, Li G, Zhao B, Sun F, Zhai Y, Zhu Y
Structure (2023) 31 pp. 295- [ Pubmed: 36649707 DOI: doi:10.1016/j.str.2022.12.013 ]
- Beryllium trifluoride ion (66 Da, Ligand)
- Aryl hydrocarbon receptor (Complex)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Aryl hydrocarbon receptor (46 kDa, Protein from Mus musculus)
- Hsp90-ahr-p23 complex (Complex from Mus musculus)
- Heat shock protein hsp 90-beta (86 kDa, Protein from Mus musculus)
- Heat shock protein hsp 90-beta (Complex from Mus musculus)
- Prostaglandin e synthase 3 (20 kDa, Protein from Mus musculus)
- Prostaglandin e synthase 3 (Complex from Mus musculus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h77
Q-score: 0.45
Wen Z, Zhang Y, Zhang B, Hang Y, Xu L, Chen Y, Xie Q, Zhao Q, Zhang L, Li G, Zhao B, Sun F, Zhai Y, Zhu Y
Structure (2023) 31 pp. 295- [ Pubmed: 36649707 DOI: doi:10.1016/j.str.2022.12.013 ]
- Beryllium trifluoride ion (66 Da, Ligand)
- Mouse hsp90-ahr-p23-xap2 complex (Complex)
- Ah receptor-interacting protein (Complex from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Aryl hydrocarbon receptor (50 kDa, Protein from Mus musculus)
- Prostaglandin e synthase 3 (20 kDa, Protein from Mus musculus)
- Heat shock protein hsp 90-beta (86 kDa, Protein from Mus musculus)
- Ah receptor-interacting protein (38 kDa, Protein from Mus musculus)
- Heat shock protein hsp 90-beta (Complex from Mus musculus)
- Aryl hydrocarbon receptor (Complex from Mus musculus)
- Prostaglandin e synthase 3 (Complex from Mus musculus)
Human L-TGF-beta1 in complex with the anchor protein LRRC33
Resolution: 4.01 Å
EM Method: Single-particle
Fitted PDBs: 7y1r
Q-score: 0.187
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ Pubmed: 36008481 DOI: doi:10.1038/s41467-022-32655-9 ]
- L-tgf-beta1 in complex with its anchor protein lrrc33 (150 kDa, Complex from Homo sapiens)
- Transforming growth factor beta activator lrrc33 (72 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7y1t
Q-score: 0.428
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ Pubmed: 36008481 DOI: doi:10.1038/s41467-022-32655-9 ]
- Integrin alpha-v (69 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- Complex of integrin alphav/beta8 and l-tgf-beta1 at a ratio of 1:2 (210 kDa, Complex from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Integrin beta-8 (53 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)