Cryo-EM structure of prefusion-stabilized RSV F (DS-Cav1 strain: A2) in complex with nAb 5B11
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8wz3
Q-score: 0.525
Liu L, Sun H, Sun Y, Zheng Q, Li S, Zheng Z, Xia N
To Be Published
- Rsv fusion glycoprotein (Complex from Mus musculus)
- 5b11 fab light chain (11 kDa, Protein from Mus musculus)
- 5b11 fab heavy chain (13 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rsv a2 pref in complex with mab 5b11 (Complex from Human respiratory syncytial virus A2)
- Rsv fusion glycoprotein (54 kDa, Protein from Human respiratory syncytial virus A2)
- 5b11 fab (Complex)
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8wz5
Q-score: 0.418
Liu L, Sun H, Sun Y, Zheng Q, Li S, Zheng Z, Xia N
To Be Published
- Rsv fusion glycoprotein (Complex from Human respiratory syncytial virus B)
- 5b11 fab light chain (11 kDa, Protein from Mus musculus)
- 5b11 fab heavy chain (12 kDa, Protein from Mus musculus)
- 5b11 fab (Complex from Mus musculus)
- Rsv b18537 pref in complex with humanized mab 5b11 (Complex)
- Rsv fusion glycoprotein (54 kDa, Protein from Human respiratory syncytial virus B)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8wze
Q-score: 0.498
Liu L, Sun H, Sun Y, Zheng Q, Li S, Zheng Z, Xia N
To Be Published
- Rsv pre-fusion glycoprotein (Complex from Mus musculus)
- 5b11 fab light chain (11 kDa, Protein from Mus musculus)
- 5b11 fab heavy chain (12 kDa, Protein from Mus musculus)
- Rsv pre-fusion glycoprotein (29 kDa, Protein from Human respiratory syncytial virus B)
- Rsv b18537 pref in complex with mab 5b11 (Complex from Human respiratory syncytial virus B)
- 5b11 fab (Complex)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8wz4
Q-score: 0.488
Liu L, Sun H, Sun Y, Zheng Q, Li S, Zheng Z, Xia N
To Be Published
- 5b11 fab (Complex)
- 5b11 fab heavy chain (13 kDa, Protein from Mus musculus)
- Rsv fusion glycoprotein (Complex from Mus musculus)
- 5b11 fab light chain (11 kDa, Protein from Mus musculus)
- Rsv a2 pref in complex with mab 5b11 (Complex from Human respiratory syncytial virus A2)
- Rsv fusion glycoprotein (54 kDa, Protein from Human respiratory syncytial virus A2)
Spo11 core complex with gapped DNA
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8urq
Q-score: 0.442
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Nat Struct Mol Biol (2025) 32 pp. 113-124 [ Pubmed: 39304764 DOI: doi:10.1038/s41594-024-01382-8 ]
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
- Gapped dna (21 kDa, DNA from Saccharomyces cerevisiae S288C)
- Meiosis-specific protein spo11 (50 kDa, Protein from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Meiotic recombination protein rec104 (20 kDa, Protein from Saccharomyces cerevisiae S288C)
- Spo11 core complex bound to gapped dna (140 kDa, Complex from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec102 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Spo11 core complex with hairpin DNA
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8uru
Q-score: 0.419
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Nat Struct Mol Biol (2025) 32 pp. 113-124 [ Pubmed: 39304764 DOI: doi:10.1038/s41594-024-01382-8 ]
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiosis-specific protein spo11 (50 kDa, Protein from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Spo11 core complex bound to gapped dna (140 kDa, Complex from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec104 (20 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec102 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Hairpin dna (14 kDa, DNA from Saccharomyces cerevisiae S288C)
CryoEM structure of recombinant human Bri2 BRICHOS oligomers
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8rnu
Q-score: 0.098
Chen G, Wang Y, Zheng Z, Jiang W, Leppert A, Zhong X, Belorusova A, Siegal G, Jegerschold C, Koeck PJB, Abelein A, Hebert H, Knight SD, Johansson J
Protein Sci (2024) 33 pp. e5063-e5063 [ DOI: doi:10.1002/pro.5063 Pubmed: 38864729 ]
- Integral membrane protein 2b (13 kDa, Protein from Homo sapiens)
- Recombinant human bri2 brichos oligomers (205 kDa, Complex from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (local refinement)
Resolution: 3.98 Å
EM Method: Single-particle
Fitted PDBs: 8ix3
Q-score: 0.451
Sun H, Wang Y, Chen X, Jiang Y, Wang S, Huang Y, Liu L, Li Y, Lan M, Guo H, Yuan Q, Zhang Y, Li T, Yu H, Gu Y, Zhang J, Li S, Zheng Z, Zheng Q, Xia N
J Virol (2023) 97 pp. e0113723-e0113723 [ Pubmed: 37855619 DOI: doi:10.1128/jvi.01137-23 ]
- Sars-cov-2 ba.4/5 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 ba.4/5 spike protein in complex with 1g11 (Complex)
- Ba.4/5 variant spike protein (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nab 1g11 (Complex from Homo sapiens)
- Light chain of 1g11 (11 kDa, Protein from Homo sapiens)
- Heavy chain of 1g11 (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (state 2)
Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (state 1)