Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8jiz
Q-score: 0.335
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in one fab bind conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8jj0
Q-score: 0.25
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in two fab conformation
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8jj1
Q-score: 0.314
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- Fab 2g7 light chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of glun1-2a nmdar in complex with human fab28 (Cell from Homo sapiens)
- Fab 2g7 heavy chain (26 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab2G7 in one fab conformation
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8jj2
Q-score: 0.274
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab2g7 heavy chain (26 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab28 (Cell from Homo sapiens)
- Fab2g7 light chain (25 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
To Be Published
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glun2a-specific antibody fragment light chain (23 kDa, Protein from Mus musculus)
- Glun1-specific antibody fragment light chain (25 kDa, Protein from Mus musculus)
- Glutamate receptor ionotropic, nmda 3a,enhanced green fluorescent protein (137 kDa, Protein from Muromegalovirus G4)
- Glutamate receptor ionotropic, nmda 2a,enhanced green fluorescent protein (125 kDa, Protein from Muromegalovirus G4)
- Triheteromeric nmda receptor glun1-glun2a-glun3a in complex with glycine, glutamate, a glun1-specific fab,and a glun2a-specific fab (Complex from Rattus norvegicus)
- Glun2a-specific antibody fragment heavy chain (24 kDa, Protein from Mus musculus)
- Glun1-specific antibody fragment heavy chain (23 kDa, Protein from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7yff
Q-score: 0.445
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (94 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (97 kDa, Protein from Homo sapiens)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Nmda receptor with nmda 1 incorperated with nmda 2d (384 MDa, Complex from Homo sapiens)
- Glycine (75 Da, Ligand)
Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7yfl
Q-score: 0.404
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2d (97 kDa, Protein from Homo sapiens)
- Nmda receptor with nmda 1 incorperated with nmda 2d (384 MDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
Structure of GluN1a E698C-GluN2D NMDA receptor in cystines crosslinked state.
Resolution: 6.4 Å
EM Method: Single-particle
Fitted PDBs: 7yfo
Q-score: 0.234
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- Nmda receptor with nmda 1 incorperated with nmda 2d (384 MDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (97 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
Structure of GluN1a E698C-GluN2D NMDA receptor in cystines non-crosslinked state.
Resolution: 5.1 Å
EM Method: Single-particle
Fitted PDBs: 7yfr
Q-score: 0.388
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (97 kDa, Protein from Homo sapiens)
- Nmda receptor with nmda 1 incorperated with nmda 2d (384 MDa, Complex from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7yfg
Q-score: 0.478
Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S
Nat Struct Mol Biol (2023) 30 pp. 629-639 [ Pubmed: 36959261 DOI: doi:10.1038/s41594-023-00959-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rat glun1-glun2c nmda receptor in complex with glycine and glutamate (Cellular component from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2c (87 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (97 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)