SpCas9-MMLV RT-pegRNA-target DNA complex (termination)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wus
Q-score: 0.454
Shuto Y, Nakagawa R, Zhu S, Hoki M, Omura SN, Hirano H, Itoh Y, Zhang F, Nureki O
Nature (2024) 631 pp. 224-231 [ DOI: doi:10.1038/s41586-024-07497-8 Pubmed: 38811740 ]
- Crispr-associated endonuclease cas9/csn1 (158 kDa, Protein from Streptococcus pyogenes serotype M1)
- Dna (40-mer) (12 kDa, DNA from Streptococcus pyogenes)
- Dna (51-mer) (15 kDa, DNA from Streptococcus pyogenes)
- Gag-pol polyprotein (55 kDa, Protein from Moloney murine leukemia virus)
- Dna (5'-d(*tp*gp*ap*tp*gp*gp*cp*ap*gp*ap*gp*tp*ap*cp*tp*ap*g)-3') (5 kDa, DNA from Streptococcus pyogenes)
- Spcas9-mmlv rt-pegrna-target dna complex (Complex from Streptococcus pyogenes)
- Rna (115-mer) (37 kDa, RNA from Streptococcus pyogenes)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8j6i
Q-score: 0.443
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ DOI: doi:10.1016/j.celrep.2023.113406 Pubmed: 37952153 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8tyl
Q-score: 0.528
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8tyo
Q-score: 0.539
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8j6j
Q-score: 0.425
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ DOI: doi:10.1016/j.celrep.2023.113406 Pubmed: 37952153 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein (Complex)
- Complex of hydroxycarboxylic acid receptor 2 with gsk256073 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8hoy
Q-score: 0.292
Xu Y, Wu Y, Zhang Y, Fan R, Yang Y, Li D, Zhu S, Yang B, Zhang Z, Dong C
Cell Res (2023) 33 pp. 479-482 [ Pubmed: 36973539 DOI: doi:10.1038/s41422-023-00796-1 ]
- Dna polymerase (120 kDa, Protein from Monkeypox virus)
- Dna polymerase processivity factor component a20 (49 kDa, Protein from Monkeypox virus)
- E4r (27 kDa, Protein from Monkeypox virus)
- Monkeypox virus replication holoenzyme f8-a22-e4 complex without dna (191 MDa, Complex from Monkeypox virus)
Cyro-EM structure of HCMV glycoprotein B in complex with 1B03 Fab
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7yrn
Q-score: 0.375
To Be Published
- Hcmv glycoprotein b (Complex from Human betaherpesvirus 5)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1b03 fab antibody light chain (23 kDa, Protein from Homo sapiens)
- 1b03 fab antibody heavy chain (23 kDa, Protein from Homo sapiens)
- 1b03 fab (Complex from Homo sapiens)
- Envelope glycoprotein b (83 kDa, Protein from Human betaherpesvirus 5)
- Hcmv glycoprotein b in complex with 1b03 fab (Complex)
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8jpd
Q-score: 0.497
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Focused refinement structure of grk2 in ntsr1-grk2-galpha(q) complexes (Complex from Bos taurus)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Staurosporine (466 Da, Ligand)
Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8jpe
Q-score: 0.447
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Focused refinement structure of galpha(q) in ntsr1-grk2-galpha(q) complexes (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
Cryo-EM structure of IRL1620-bound ETBR-Gi complex
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8hbd
Q-score: 0.412
Ji Y, Duan J, Yuan Q, He X, Yang G, Zhu S, Wu K, Hu W, Gao T, Cheng X, Jiang H, Eric Xu H, Jiang Y
Nat Commun (2023) 14 pp. 1268-1268 [ DOI: doi:10.1038/s41467-023-36998-9 Pubmed: 36882417 ]
- Irl1620-bound etbr-gi complex (Complex from Homo sapiens)
- Endothelin receptor type b,endothelin receptor type b,oplophorus-luciferin 2-monooxygenase catalytic subunit chimera (67 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Irl1620 (1 kDa, Protein from Homo sapiens)